Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation

Sorby-Adams, Annabel J.; Learoyd, Annastazia E.; Bath, Philip M.; Burrows, Fiona; Farr, Tracy D.; Leonard, Anna V.; Schiessl, Ingo; Allan, Stuart M.; Turner, Renée J.; Trueman, Rebecca C.

doi:10.1177/0271678X211018901

All Outputs (2)

Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains (2021)
Journal Article
Elvers, K. T., Lipka-Lloyd, M., Trueman, R. C., Bax, B. D., & Mehellou, Y. (2022). Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains. ChemBioChem, 23(1), Article e202100441. https://doi.org/10.1002/cbic.202100441

STE20/SPS1-related proline/alanine-rich kinase (SPAK) and oxidative stress responsive 1 (OSR1) kinase are two serine/threonine protein kinases that regulate the function of ion co-transporters through phosphorylation. The highly conserved C-terminal... Read More about Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.

Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation (2021)
Journal Article
Sorby-Adams, A. J., Learoyd, A. E., Bath, P. M., Burrows, F., Farr, T. D., Leonard, A. V., …Trueman, R. C. (2021). Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation. Journal of Cerebral Blood Flow and Metabolism, 41(12), 3248-3259. https://doi.org/10.1177/0271678X211018901

Hypertension is a leading risk factor for death and dependency after ischaemic stroke. However, administering anti-hypertensive medications post-stroke remains contentious with concerns regarding deleterious effects on cerebral blood flow and infarct... Read More about Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation.