All Outputs (3)

Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer's disease mice (2022)
Journal Article
Diaz-Amarilla, P., Arredondo, F., Dapueto, R., Boix, V., Carvalho, D., Santi, M. D., …Savio, E. (2022). Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer's disease mice. Neurochemistry International, 159, Article 105403. https://doi.org/10.1016/j.neuint.2022.105403

Alzheimer's disease has been considered mostly as a neuronal pathology, although increasing evidence suggests that glial cells might play a key role in the disease onset and progression. In this sense, astrocytes, with their central role in neuronal... Read More about Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer's disease mice.

Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves (2021)
Journal Article
Mesquita-Ribeiro, R., Fort, R. S., Rathbone, A., Farias, J., Lucci, C., James, V., …Dajas-Bailador, F. (2021). Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves. RNA Biology, 18(sup2), 832-855. https://doi.org/10.1080/15476286.2021.2000792

Neurons have highlighted the needs for decentralized gene expression and specific RNA function in somato-dendritic and axonal compartments, as well as in intercellular communication via extracellular vesicles (EVs). Despite advances in miRNA biology,... Read More about Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves.

PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses (2020)
Journal Article
Di Paolo, A. P., Eastman, G., Mesquita Ribeiro, R., Farias, J., Macklin, A., Kislinger, T., …Sotelo Silveira, J. R. (2020). PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses. RNA, 26(11), 1637-1653. https://doi.org/10.1261/rna.075424.120

© 2020 Di Paolo et al. Programmed cell death 4 (PDCD4) protein is a tumor suppressor that inhibits translation through the mTOR-dependent initiation factor EIF4A, but its functional role and mRNA targets in neurons remain largely unknown. Our work id... Read More about PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.