Principles of early human development and germ cell program from conserved model systems

Kobayashi, Toshihiro; Zhang, Haixin; Tang, walfred; Irie, Naoko; Withey, Sarah; Klisch, Doris; Sybirna, Anastasiya; Contreras, D.; Webb, Robert; Allegrucci, Cinzia; Alberio, Ramiro; Surani, M.

doi:10.1038/nature22812

All Outputs (2)

Transcriptional and epigenetic control of cell fate decisions in early embryos (2017)
Journal Article
Alberio, R. (2017). Transcriptional and epigenetic control of cell fate decisions in early embryos. Reproduction, Fertility and Development, 30(1), https://doi.org/10.1071/RD17403

Mammalian embryo development is characterized by regulative mechanisms of lineage segregation and cell specification. A combination of carefully orchestrated gene expression networks, signalling pathways and epigenetic marks define specific developme... Read More about Transcriptional and epigenetic control of cell fate decisions in early embryos.

Principles of early human development and germ cell program from conserved model systems (2017)
Journal Article
Kobayashi, T., Zhang, H., Tang, W., Irie, N., Withey, S., Klisch, D., …Surani, M. (2017). Principles of early human development and germ cell program from conserved model systems. Nature, 546, https://doi.org/10.1038/nature22812

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development(1). Using in vitro models of hPGC induction(2-4), recent studies suggest striking mechanistic differences in specif... Read More about Principles of early human development and germ cell program from conserved model systems.