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All Outputs (12)

The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project (2024)
Journal Article
Jefferson, E., Milligan, G., Johnston, J., Mumtaz, S., Cole, C., Best, J., Giles, T. C., Cox, S., Masood, E., Horban, S., Urwin, E., Beggs, J., Chuter, A., Reilly, G., Morris, A., Seymour, D., Hopkins, S., Sheikh, A., & Quinlan, P. (2024). The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project. Journal of Medical Internet Research, 26, Article e50235. https://doi.org/10.2196/50235

The COVID-19-Curated and Open Analysis and Research Platform (CO-CONNECT) project worked with 22 organizations across the United Kingdom to build a federated platform, enabling researchers to instantaneously and dynamically query federated datasets t... Read More about The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project.

Lessons from the PROTECT-CH COVID-19 platform trial in care homes (2024)
Journal Article
Bath, P. M., Ball, J., Boyd, M., Gage, H., Glover, M., Godfrey, M., Guthrie, B., Hewitt, J., Howard, R., Jaki, T., Juszczak, E., Lasserson, D., Leighton, P., Leyland, V., Shen Lim, W., Logan, P., Meakin, G., Montgomery, A., Ogollah, R., Passmore, P., …Gordon, A. L. (in press). Lessons from the PROTECT-CH COVID-19 platform trial in care homes. Health Technology Assessment,

A SARS-CoV-2 minimum data standard to support national serology reporting (2024)
Journal Article
Urwin, E. N., Martin, J., Sebire, N., Harris, A., Johnson, J., Masood, E., Milligan, G., Mairs, L., Chuter, A., Ferguson, M., Quinlan, P., & Jefferson, E. (2024). A SARS-CoV-2 minimum data standard to support national serology reporting. Annals of Clinical Biochemistry, 61(6), 418-445. https://doi.org/10.1177/00045632241261274

Background: Healthcare laboratory systems produce and capture a vast array of information, yet do not always report all of this to the national infrastructure within the United Kingdom. The global COVID-19 pandemic brought about a much greater need f... Read More about A SARS-CoV-2 minimum data standard to support national serology reporting.

Dynamic early warning scores for predicting clinical deterioration in patients with respiratory disease (2022)
Journal Article
Gonem, S., Taylor, A., Figueredo, G., Forster, S., Quinlan, P., Garibaldi, J. M., McKeever, T. M., & Shaw, D. (2022). Dynamic early warning scores for predicting clinical deterioration in patients with respiratory disease. Respiratory Research, 23, Article 203. https://doi.org/10.1186/s12931-022-02130-6

Background: The National Early Warning Score-2 (NEWS-2) is used to detect patient deterioration in UK hospitals but fails to take account of the detailed granularity or temporal trends in clinical observations. We used data-driven methods to develop... Read More about Dynamic early warning scores for predicting clinical deterioration in patients with respiratory disease.

A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study (2022)
Journal Article
Jefferson, E., Cole, C., Mumtaz, S., Cox, S., Giles, T., Adejumo, S., …Quinlan, P. (2022). A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study. Journal of Medical Internet Research, 24(12), Article e40035. https://doi.org/10.2196/40035

Background:
COVID-19 data have been generated across the United Kingdom as a by-product of clinical care and public health provision, as well as numerous bespoke and repurposed research endeavors. Analysis of these data has underpinned the United Ki... Read More about A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study.

Lessons learned from the COVID-19 pandemic about sample access for research in the UK (2022)
Journal Article
Mai Sims, J., Lawrence, E., Glazer, K., Gander, A., Fuller, B., Garibaldi, J., …Quinlan, P. R. (2022). Lessons learned from the COVID-19 pandemic about sample access for research in the UK. BMJ Open, 12(4), Article e047309. https://doi.org/10.1136/bmjopen-2020-047309

Objective Annotated clinical samples taken from patients are a foundation of translational medical research and give mechanistic insight into drug trials. Prior research by the Tissue Directory and Coordination Centre (TDCC) indicated that researcher... Read More about Lessons learned from the COVID-19 pandemic about sample access for research in the UK.

Cluster analyses of the TCGA and a TMA dataset using the coexpression of HSP27 and CRYAB improves alignment with clinical-pathological parameters of breast cancer and suggests different epichaperome influences for each sHSP (2022)
Journal Article
Quinlan, P. R., Figeuredo, G., Mongan, N., Jordan, L. B., Bray, S. E., Sreseli, R., …Quinlan, R. A. (2022). Cluster analyses of the TCGA and a TMA dataset using the coexpression of HSP27 and CRYAB improves alignment with clinical-pathological parameters of breast cancer and suggests different epichaperome influences for each sHSP. Cell Stress and Chaperones, 27(2), 177-188. https://doi.org/10.1007/s12192-022-01258-0

Our cluster analysis of the Cancer Genome Atlas for co-expression of HSP27 and CRYAB in breast cancer patients identified three patient groups based on their expression level combination (high HSP27 + low CRYAB; low HSP27 + high CRYAB; similar HSP27 ... Read More about Cluster analyses of the TCGA and a TMA dataset using the coexpression of HSP27 and CRYAB improves alignment with clinical-pathological parameters of breast cancer and suggests different epichaperome influences for each sHSP.

The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure (2022)
Journal Article
Gordon, A. L., Rick, C., Juszczak, E., Montgomery, A., Howard, R., Guthrie, B., …Tate, V. (2022). The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure. Age and Ageing, 51(3), Article afac052. https://doi.org/10.1093/ageing/afac052

The COVID-19 pandemic resulted in catastrophic levels of morbidity and mortality for care home residents. Despite this, research platforms for COVID-19 in care homes arrived late in the pandemic compared with other care settings. The Prophylactic The... Read More about The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure.

Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation (2020)
Journal Article
Napoli, M., Li, X., Ackerman, H. D., Deshpande, A. A., Barannikov, I., Pisegna, M. A., …Flores, E. R. (2020). Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation. Nature Communications, 11, Article 5156. https://doi.org/10.1038/s41467-020-18973-w

The most frequent genetic alterations across multiple human cancers are mutations in TP53 and the activation of the PI3K/AKT pathway, two events crucial for cancer progression. Mutations in TP53 lead to the inhibition of the tumour and metastasis sup... Read More about Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation.

Study protocol for a multicentre longitudinal mixed methods study to explore the Outcomes of ChildrEn and fAmilies in the first year after paediatric Intensive Care: the OCEANIC study (2020)
Journal Article
Manning, J. C., Latour, J. M., Curley, M. A. Q., Draper, E. S., Jilani, T., Quinlan, P. R., …Coad, J. (2020). Study protocol for a multicentre longitudinal mixed methods study to explore the Outcomes of ChildrEn and fAmilies in the first year after paediatric Intensive Care: the OCEANIC study. BMJ Open, 10(5), Article e038974. https://doi.org/10.1136/bmjopen-2020-038974

Introduction Annually in the UK, 20 000 children become very ill or injured and need specialist care within a paediatric intensive care unit (PICU). Most children survive. However, some children and their families may experience problems after they h... Read More about Study protocol for a multicentre longitudinal mixed methods study to explore the Outcomes of ChildrEn and fAmilies in the first year after paediatric Intensive Care: the OCEANIC study.

Development of a pre-operative scoring system for predicting risk of post-operative paediatric cerebellar mutism syndrome (2018)
Journal Article
Liu, J.-F., Dineen, R. A., Avula, S., Chambers, T., Dutta, M., Jaspan, T., MacArthur, D. C., Howarth, S., Soria, D., Quinlan, P., Harave, S., Ong, C. C., Mallucci, C. L., Kumar, R., Pizer, B., & Walker, D. A. (in press). Development of a pre-operative scoring system for predicting risk of post-operative paediatric cerebellar mutism syndrome. British Journal of Neurosurgery, https://doi.org/10.1080/02688697.2018.1431204

BACKGROUND: Despite previous identification of pre-operative clinical and radiological predictors of post-operative paediatric cerebellar mutism syndrome (CMS), a unifying pre-operative risk stratification model for use during surgical consent is cur... Read More about Development of a pre-operative scoring system for predicting risk of post-operative paediatric cerebellar mutism syndrome.