Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence
(2022)
Journal Article
Gao, X., Frakich, N., Filippini, P., Edwards, L. J., Vinkemeier, U., Gran, B., Tanasescu, R., Bayraktutan, U., Colombo, S., & Constantinescu, C. S. (2022). Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence. Neuropeptides, 95, Article 102265. https://doi.org/10.1016/j.npep.2022.102265
The neuropeptide substance P (SP) mediates pain transmission, immune modulation, vasodilation and neurogenic inflammation. Its role in the peripheral nervous system has been well characterised. However, its actions on the blood-brain barrier (BBB) ar... Read More about Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence.