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Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men (2017)
Journal Article
Mitchell, W. K., Phillips, B. E., Hill, I., Greenhaff, P. L., Lund, J. N., Williams, J. P., …Atherton, P. J. (2017). Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men. Clinical Science, 131(21), https://doi.org/10.1042/CS20171230

Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the e... Read More about Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.

Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women (2017)
Journal Article
Wilkinson, D. J., Bukhari, S. S., Phillips, B. E., Limb, M. C., Cegielski, J., Brook, M. S., …Atherton, P. J. (2018). Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women. Clinical Nutrition, 37(6), 2011-2021. https://doi.org/10.1016/j.clnu.2017.09.008

© 2017 The Authors Background & aims: Impaired anabolic responses to nutrition and exercise contribute to loss of skeletal muscle mass with ageing (sarcopenia). Here, we tested responses of muscle protein synthesis (MPS), in the under represented gr... Read More about Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women.

Physiological adaptations to resistance exercise as a function of age (2017)
Journal Article
Phillips, B. E., Williams, J. P., Greenhaff, P. L., Smith, K., & Atherton, P. J. (2017). Physiological adaptations to resistance exercise as a function of age. JCI insight, 2(17), Article e95581. https://doi.org/10.1172/jci.insight.95581

BACKGROUND. The impact of resistance exercise training (RE-T) across the life span is poorly defined. METHODS. To resolve this, we recruited three distinct age cohorts of young (18–28 years; n = 11), middle-aged (45–55 years; n = 20), and... Read More about Physiological adaptations to resistance exercise as a function of age.

Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review (2016)
Journal Article
Rudrappa, S. S., Wilkinson, D., Greenhaff, P. L., Smith, K., Idris, I., & Atherton, P. J. (2016). Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review. Frontiers in Physiology, 7(361), https://doi.org/10.3389/fphys.2016.00361

The ever increasing burden of an ageing population and pandemic of metabolic syndrome worldwide demands further understanding of the modifiable risk factors in reducing disability and morbidity associated with these conditions. Disuse skeletal muscle... Read More about Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review.

Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24h of recovery following prolonged exhaustive exercise in humans (2016)
Journal Article
Roberts, P. A., Fox, J., Peirce, N., Jones, S. W., Casey, A., & Greenhaff, P. L. (2016). Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24h of recovery following prolonged exhaustive exercise in humans. Amino Acids, 48(8), 1831–1842. https://doi.org/10.1007/s00726-016-2252-x

Muscle glycogen availability can limit endurance exercise performance. We previously demonstrated 5 days of creatine (Cr) and carbohydrate (CHO) ingestion augmented post-exercise muscle glycogen storage compared to CHO feeding alone in healthy volunt... Read More about Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24h of recovery following prolonged exhaustive exercise in humans.

The effect of age and unilateral leg immobilisation for 2 weeks on substrate ulilisation during moderate-intensity exercise in human skeletal muscle (2016)
Journal Article
Vigelsø, A., Gram, M., Dybboe, R., Kuhlman, A., Prats, C., Greenhaff, P. L., …Helge, J. (2016). The effect of age and unilateral leg immobilisation for 2 weeks on substrate ulilisation during moderate-intensity exercise in human skeletal muscle. Journal of Physiology, 594(8), 2339-2358. https://doi.org/10.1113/jp271712

Age and inactivity have been associated with intramuscular triglyceride (IMTG) accumulation. Here, we attempt to disentangle these factors by studying the effect of 2 weeks of unilateral leg immobilization on substrate utilization across the legs dur... Read More about The effect of age and unilateral leg immobilisation for 2 weeks on substrate ulilisation during moderate-intensity exercise in human skeletal muscle.

Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men (2015)
Journal Article
Shannon, C. E., Nixon, A. V., Greenhaff, P. L., & Stephens, F. B. (2016). Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men. American Journal of Clinical Nutrition, 103(1), https://doi.org/10.3945/ajcn.115.119826

BACKGROUND: Increasing skeletal muscle carnitine content represents an appealing intervention in conditions of perturbed lipid metabolism such as obesity and type 2 diabetes but requires chronic L-carnitine feeding on a daily basis in a high-carbo... Read More about Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men.

The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans (2014)
Journal Article

The integrin-adhesome network, which contains >150 proteins, is mechano-transducing and located at discreet positions along the cell-cell and cell-extracellular matrix interface. A small subset of the integrin-adhesome is known to maintain normal mus... Read More about The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans.