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All Outputs (125)

The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England (2017)
Journal Article

Background: Pregnant women may have an increased risk of stroke compared to non-pregnant women of similar age, but the magnitude and the timing of such risk are unclear. We examined the risk of first stroke event in women of childbearing age and comp... Read More about The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England.

Continuing or temporarily stopping prestroke antihypertensive medication in acute stroke: an individual patient data meta-analysis (2017)
Journal Article

Over 50% of patients are already taking blood pressure–lowering therapy on hospital admission for acute stroke. An individual patient data meta-analysis from randomized controlled trials was undertaken to determine the effect of continuation versus t... Read More about Continuing or temporarily stopping prestroke antihypertensive medication in acute stroke: an individual patient data meta-analysis.

Baseline characteristics of the 3,096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial (2016)
Journal Article

Background: The risk of recurrence following ischaemic stroke (IS) or transient ischaemic attack (TIA) is highest immediately after the event. Antiplatelet agents are effective in reducing the risk of recurrence and two agents are superior to one in... Read More about Baseline characteristics of the 3,096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial.

Treatment of intracerebral haemorrhage with tranexamic acid: a review of current evidence and ongoing trials (2016)
Journal Article

Purpose Haematoma expansion is a devastating complication of intracerebral haemorrhage with no established treatment. Tranexamic acid had been an effective haemostatic agent in reducing post-operative and traumatic bleeding. We review current evide... Read More about Treatment of intracerebral haemorrhage with tranexamic acid: a review of current evidence and ongoing trials.

Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2(right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor (2016)
Journal Article

Rationale High blood pressure (BP) is common in acute stroke and is associated with poor outcome. Previous hospital-based trials testing the effects of BP lowering on functional outcome have been inconclusive. The PIL-FAST and RIGHT pilot trials conf... Read More about Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2(right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor.

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research (2016)
Journal Article

Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuse... Read More about METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research.