All Outputs (3)

Generation of Hepatocytes from Pluripotent Stem Cells for Drug Screening and Developmental Modeling. (2014)
Journal Article

Hepatocytes produced from the differentiation of human pluripotent stem cells can be used to study human development and liver disease, to investigate the toxicological response of novel drug candidates, and as an alternative source of primary cells... Read More about Generation of Hepatocytes from Pluripotent Stem Cells for Drug Screening and Developmental Modeling..

Disease modeling using human induced pluripotent stem cells: lessons from the liver (2014)
Journal Article

Human pluripotent stem cells (hPSCs) have the capacity to differentiate into any of the hundreds of distinct cell types that comprise the human body. This unique characteristic has resulted in considerable interest in the field of regenerative medici... Read More about Disease modeling using human induced pluripotent stem cells: lessons from the liver.

Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture (2014)
Journal Article
Gieseck, R. L., Hannan, N. R., Gieseck III, R., Bort, R., Hanley, N., Drake, R., …Vallier, L. (2014). Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture. PLoS ONE, 9(1), Article e86372. https://doi.org/10.1371/journal.pone.0086372

Induced pluripotent stem cell derived hepatocytes (IPSC-Heps) have the potential to reduce the demand for a dwindling number of primary cells used in applications ranging from therapeutic cell infusions to in vitro toxicology studies. However, curren... Read More about Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture.