All Outputs (5)

Priming from within: TLR2 dependent but receptor independent activation of the mammary macrophage inflammasome by Streptococcus uberis (2024)
Journal Article
Hinds, A., Ward, P., Archer, N., & Leigh, J. (2024). Priming from within: TLR2 dependent but receptor independent activation of the mammary macrophage inflammasome by Streptococcus uberis. Frontiers in Cellular and Infection Microbiology, 14, Article 1444178. https://doi.org/10.3389/fcimb.2024.1444178

Introduction: Streptococcus uberis is a member of the pyogenic cluster of Streptococcus commonly associated with intramammary infection and mastitis in dairy cattle. It is a poorly controlled globally endemic pathogen responsible for a significant ca... Read More about Priming from within: TLR2 dependent but receptor independent activation of the mammary macrophage inflammasome by Streptococcus uberis.

The expanding role of cap-adjacent modifications in animals (2024)
Journal Article
Bellows, E., Fray, R. G., Knight, H. M., & Archer, N. (2024). The expanding role of cap-adjacent modifications in animals. Frontiers in RNA Research, 2, Article 1485307. https://doi.org/10.3389/frnar.2024.1485307

Eukaryotic mRNA cap structures directly influence mRNA stability, translation, and immune recognition. While the significance of the mRNA cap itself has been well-established, recent research has revealed the intricate modifications to the nucleotide... Read More about The expanding role of cap-adjacent modifications in animals.

Epitranscriptomic mechanisms of androgen signalling and prostate cancer (2024)
Journal Article
Patke, R., Harris, A. E., Woodcock, C. L., Thompson, R., Santos, R., Kumari, A., Allegrucci, C., Archer, N., Gudas, L. J., Robinson, B. D., Persson, J. L., Fray, R., Jeyapalan, J., Rutland, C. S., Rakha, E., Madhusudan, S., Emes, R. D., Muyangwa-Semenova, M., Alsaleem, M., de Brot, S., …Lothion-Roy, J. (2024). Epitranscriptomic mechanisms of androgen signalling and prostate cancer. Neoplasia, 56, Article 101032. https://doi.org/10.1016/j.neo.2024.101032

Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating localised disease, post-treatment recurrence is common. As the androgen receptor (AR) and androgen... Read More about Epitranscriptomic mechanisms of androgen signalling and prostate cancer.

Comparative transcriptome reprogramming in oak galls containing asexual or sexual generations of gall wasps (2024)
Journal Article
Bellows, E., Heatley, M., Shah, N., Archer, N., Giles, T., & Fray, R. (2024). Comparative transcriptome reprogramming in oak galls containing asexual or sexual generations of gall wasps. Plant Biology, 26(5), 798-810. https://doi.org/10.1111/plb.13670

Oak gall wasps have evolved strategies to manipulate the developmental pathways of their host to induce gall formation. This provides shelter and nutrients for the developing larva. Galls are entirely host tissue; however, the initiation, development... Read More about Comparative transcriptome reprogramming in oak galls containing asexual or sexual generations of gall wasps.

Reproducible isolation of bovine mammary macrophages for analysis of host pathogen interactions (2024)
Journal Article
Tomes, A., Archer, N., & Leigh, J. (2024). Reproducible isolation of bovine mammary macrophages for analysis of host pathogen interactions. BMC Veterinary Research, 20, Article 96. https://doi.org/10.1186/s12917-024-03944-w

Background: Macrophages residing in milk are vital during intramammary infections. This study sought to develop a method enabling the investigation of macrophage responses to pathogens. Streptococcus uberis is the predominant cause of bovine mastitis... Read More about Reproducible isolation of bovine mammary macrophages for analysis of host pathogen interactions.