All Outputs (68)

Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia: an evidence review group perspective of a NICE single technology appraisal (2017)
Journal Article
Carroll, C., Tappenden, P., Rafia, R., Hamilton, J., Chambers, D., Clowes, M., …Wierzbicki, A. S. (2017). Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia: an evidence review group perspective of a NICE single technology appraisal. PharmacoEconomics, 35, 537-547. https://doi.org/10.1007/s40273-017-0492-6

As part of its single technology appraisal (STA) process, the UK National Institute for Health and Care Excellence (NICE) invited the manufacturer of evolocumab (Amgen) to submit evidence on the clinical and cost effectiveness of evolocumab. The appr... Read More about Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia: an evidence review group perspective of a NICE single technology appraisal.

Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis (2017)
Journal Article
Little, I., Vinogradova, Y., Orton, E., Kai, J., & Qureshi, N. (2017). Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis. BMJ Open, 7(3), Article e012665. https://doi.org/10.1136/bmjopen-2016-012665

Objective: To determine whether sickle cell carriers (‘sickle cell trait’) have an increased risk of venous thromboembolism (VTE). Design: Cohort study with nested case-control analysis. Setting: General population with data from 609 UK gener... Read More about Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis.

An automated software system to promote anticoagulation and reduce stroke risk: cluster-randomized controlled trial (2017)
Journal Article
Holt, T. A., Dalton, A., Marshall, T., Fay, M., Qureshi, N., Kirkpatrick, S., …Fitzmaurice, D. (2017). An automated software system to promote anticoagulation and reduce stroke risk: cluster-randomized controlled trial. Stroke, 48(3), 787-790

Background and Purpose: Oral anticoagulants (OAC) substantially reduce risk of stroke in atrial fibrillation, but uptake is suboptimal. Electronic health records enable automated identification of people at risk but not receiving treatment. We inve... Read More about An automated software system to promote anticoagulation and reduce stroke risk: cluster-randomized controlled trial.

Feasibility of improving identification of familial hypercholesterolaemia in general practice: intervention development study (2016)
Journal Article
Qureshi, N., Weng, S., Tranter, J., El-Kadiki, A., & Kai, J. (2016). Feasibility of improving identification of familial hypercholesterolaemia in general practice: intervention development study. BMJ Open, 6, Article e011734. https://doi.org/10.1136/bmjopen-2016-011734

Objectives: To assess the feasibility of improving identification of familial hypercholesterolaemia (FH) in primary care, and of collecting outcome measures to inform a future trial. Design: Feasibility intervention study. Setting: 6 general practi... Read More about Feasibility of improving identification of familial hypercholesterolaemia in general practice: intervention development study.

The role of cost-effectiveness analysis in the development of indicators to support incentive-based behaviour in primary care in England (2016)
Journal Article
Qureshi, N., Weng, S., & Hex, N. (in press). The role of cost-effectiveness analysis in the development of indicators to support incentive-based behaviour in primary care in England. Journal of Health Services Research and Policy, https://doi.org/10.1177/1355819616650912

In England, general practitioners are incentivized through a national pay-for-performance scheme to adopt evidence-based quality improvement initiatives using a portfolio of Quality and Outcomes Framework (QOF) indicators. We describe the development... Read More about The role of cost-effectiveness analysis in the development of indicators to support incentive-based behaviour in primary care in England.

Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study (2015)
Journal Article
Qureshi, N., Kai, J., Middlemass, J., Dhiman, P., Cross-Bardell, L., Acharya, J., …Standen, P. (2015). Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study. Primary Health Care Research and Development, 16(6), 607-617. https://doi.org/10.1017/S1463423615000122

Aim: This study assesses the feasibility of collecting genetic samples and self-reported outcome measures after cardiovascular risk assessment, and presenting the genetic test results to participants. Background: Coronary heart disease (CHD) genetic... Read More about Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study.

Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study (2015)
Journal Article
Cross-Bardell, L., George, T., Bhoday, M., Tuomainen, H., Qureshi, N., & Kai, J. (2015). Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study. BMJ Open, 5(2), Article e007317. https://doi.org/10.1136/bmjopen-2014-007317

Objectives To explore perspectives on enhancing physical activity and diet among South Asians in urban deprived communities at high risk of chronic disease and to inform development of culturally appropriate health promotion intervention. Des... Read More about Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study.

Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening (2014)
Journal Article

Universal newborn screening for sickle cell disorders and cystic fibrosis aims to enable the early identification and treatment of affected babies. Screening can also identify infants who are healthy carriers, with carrier results being the commonest... Read More about Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening.