Implementing HLA-B*58:01 testing prior to allopurinol initiation in Malaysian primary care setting: A qualitative study from doctors’ and patients’ perspective

Ng, Wei Leik; Hussein, Norita; Ng, Chirk Jenn; Qureshi, Nadeem; Lee, Yew Kong; Kwan, Zhenli; Kee, Boon Pin; Then, Sue Mian; Abdul Malik, Tun Firzara; Mohd Zaidan, Fatimah Zahrah; Azmi, Siti Umi Fairuz

doi:10.1371/journal.pone.0296498

All Outputs (3)

Prevalence and distributions of severely elevated low-density lipoprotein cholesterol (LDL-c) according to age, gender and clinic location among patients in the Malaysian primary care (2024)
Journal Article
Kanchau, J. D., Akyea, R. K., Baharudin, N., Mohamed-Yassin, M., Kamal, A., Chua, Y., …Ramli, A. S. (2024). Prevalence and distributions of severely elevated low-density lipoprotein cholesterol (LDL-c) according to age, gender and clinic location among patients in the Malaysian primary care. Clinical Epidemiology and Global Health, 27, Article 101619. https://doi.org/10.1016/j.cegh.2024.101619

Background Adults with severely elevated low-density lipoprotein cholesterol (LDL-c) may have familial hypercholesterolaemia (FH) and are at high risk of atherosclerotic cardiovascular disease (ASCVD). The prevalence of elevated LDL-c in primary car... Read More about Prevalence and distributions of severely elevated low-density lipoprotein cholesterol (LDL-c) according to age, gender and clinic location among patients in the Malaysian primary care.

A case report of heterozygous familial hypercholesterolaemia with LDLR gene mutation complicated by premature coronary artery disease detected in primary care (2024)
Journal Article
Abdul-Halim, M. A. Z., Abdul-Hamid, H., Baharudin, N., Mohamed-Yassin, M., Kasim, S. S., Nawawi, H., …Ramli, A. S. (2024). A case report of heterozygous familial hypercholesterolaemia with LDLR gene mutation complicated by premature coronary artery disease detected in primary care. European Heart Journal: Case Reports, 8(2), Article ytae039. https://doi.org/10.1093/ehjcr/ytae039

Background: Familial hypercholesterolaemia (FH) is an autosomal dominant genetic condition predominantly caused by the low-density lipoprotein receptor (LDLR) gene mutation. Case summary: This is the case of a 54-year-old Malay woman with genetically... Read More about A case report of heterozygous familial hypercholesterolaemia with LDLR gene mutation complicated by premature coronary artery disease detected in primary care.

Implementing HLA-B*58:01 testing prior to allopurinol initiation in Malaysian primary care setting: A qualitative study from doctors’ and patients’ perspective (2024)
Journal Article
Ng, W. L., Hussein, N., Ng, C. J., Qureshi, N., Lee, Y. K., Kwan, Z., …Azmi, S. U. F. (2024). Implementing HLA-B*58:01 testing prior to allopurinol initiation in Malaysian primary care setting: A qualitative study from doctors’ and patients’ perspective. PLoS ONE, 19(1), e0296498. https://doi.org/10.1371/journal.pone.0296498

Introduction Allopurinol, the first-line treatment for chronic gout, is a common causative drug for severe cutaneous adverse reactions (SCAR). HLA-B*58:01 allele was strongly associated with allopurinol-induced SCAR in Asian countries such as Taiwan,... Read More about Implementing HLA-B*58:01 testing prior to allopurinol initiation in Malaysian primary care setting: A qualitative study from doctors’ and patients’ perspective.