Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future

Bassotti, Gabrio; Villanacci, Vincenzo; Corsetti, Maura

doi:10.3390/jcm12041702

All Outputs (9)

Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial (2023)
Journal Article
Gunn, D., Topan, R., Fried, R., Holloway, I., Brindle, R., Hartley, S., …Spiller, R. (2023). Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial. Efficacy and Mechanism Evaluation, 10(9), 1-154. https://doi.org/10.3310/ytfw7874

Background: Irritable bowel syndrome with diarrhoea is characterised by frequent, loose or watery stools with associated urgency, resulting in marked reduction of quality of life. Ondansetron, a 5-hydroxytryptamine-3 receptor antagonist, has been sho... Read More about Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial.

Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document (2023)
Journal Article
Brenner, D. M., Corsetti, M., Drossman, D., Tack, J., & Wald, A. (2024). Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document. Clinical Gastroenterology and Hepatology, 22(2), 397-412. https://doi.org/10.1016/j.cgh.2023.08.044

Background & Aims: Functional constipation is the most common of the disorders of gut-brain interaction, affecting approximately 12% of the world population. Although classically considered a chronic condition, many individuals experience shorter yet... Read More about Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document.

Neurogastroenterology and Motility gets younger! (2023)
Journal Article
Corsetti, M., Shin, A., Black, C., Keszthelyi, D., Christofi, F. L., Zerbib, F., …Jones, M. (2023). Neurogastroenterology and Motility gets younger!. Neurogastroenterology and Motility, 35(10), Article e14665. https://doi.org/10.1111/nmo.14665

Appropriate use of p-values (2023)
Journal Article
Jones, M. P., Browning, K., Corsetti, M., Keszthelyi, D., Shin, A., Singh, R., …Zerbib, F. (2023). Appropriate use of p-values. Neurogastroenterology and Motility, 35(11), Article e14664. https://doi.org/10.1111/nmo.14664

Symptom Subgroups Taking Into Account Psychological Burden Predicts Irritable Bowel Syndrome Disease Impact and Burden: A Step Forward? (2023)
Journal Article
Corsetti, M., & Ballou, S. (2023). Symptom Subgroups Taking Into Account Psychological Burden Predicts Irritable Bowel Syndrome Disease Impact and Burden: A Step Forward?. Clinical Gastroenterology and Hepatology, https://doi.org/10.1016/j.cgh.2023.04.032

The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study (2023)
Journal Article
Jaafari, H., Houghton, L. A., West, R. M., Agrawal, A., Aziz, I., Black, C. J., …Vasant, D. H. (2023). The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study. Neurogastroenterology and Motility, 35(6), Article e14574. https://doi.org/10.1111/nmo.14574

Background: There are minimal epidemiological data comparing the burden of disorders of gut brain interaction (DGBI) in the UK with other countries. We compared the prevalence of DGBI in the UK with other countries that participated in the Rome Found... Read More about The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study.

News from the Editors (2023)
Journal Article
Corsetti, M., Zerbib, F., Black, C., Shin, A., Browning, K., Chistofi, F., & Keszthelyi, D. (2023). News from the Editors. Neurogastroenterology and Motility, 35(5), Article e14590. https://doi.org/10.1111/nmo.14590

Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future (2023)
Journal Article
Bassotti, G., Villanacci, V., & Corsetti, M. (2023). Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future. Journal of Clinical Medicine, 12(4), Article 1702. https://doi.org/10.3390/jcm12041702

Despite great progress in pharmaceutical research, the medical treatment of chronic idiopathic constipation is far from ideal. The aim of the present article was to review literature data, focusing on poorly studied or commercially unavailable/unappr... Read More about Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future.