Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation
(2015)
Journal Article
Mansor, L. S., Mehta, K., Aksentijevic, D., Carr, C. A., Lund, T., Cole, M. A., …Heather, L. C. (2016). Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation. Journal of Physiology, 594(2), 307-320. https://doi.org/10.1113/JP271242
Hypoxia activates the hypoxia-inducible factor (HIF), promoting glycolysis and suppressing mitochondrial respiration. In the type 2 diabetic heart, glycolysis is suppressed whereas fatty acid metabolism is promoted. The diabetic heart experiences chr... Read More about Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation.