NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl

Simpson, Luke A; Crowley, Darren; Forey, Teri; Acosta, Helena; Ferjentsik, Zoltan; Chatfield, Jodie; Payne, Alexander; Simpson, Benjamin S; Redwood, Catherine; Dixon, James E; Holmes, Nadine; Sang, Fei; Alberio, Ramiro; Loose, Matthew; Johnson, Andrew D

doi:10.1371/journal.pbio.3002121

All Outputs (3)

A single-cell atlas of pig gastrulation as a resource for comparative embryology (2024)
Journal Article
Simpson, L., Strange, A., Klisch, D., Kraunsoe, S., Azami, T., Goszczynski, D., …Alberio, R. (2024). A single-cell atlas of pig gastrulation as a resource for comparative embryology. Nature Communications, 15(1), Article 5210. https://doi.org/10.1038/s41467-024-49407-6

Cell-fate decisions during mammalian gastrulation are poorly understood outside of rodent embryos. The embryonic disc of pig embryos mirrors humans, making them a useful proxy for studying gastrulation. Here we present a single-cell transcriptomic at... Read More about A single-cell atlas of pig gastrulation as a resource for comparative embryology.

Interspecies control of development during mammalian gastrulation (2023)
Journal Article
Simpson, L., & Alberio, R. (2023). Interspecies control of development during mammalian gastrulation. Emerging Topics in Life Sciences, 7(4), 397-408. https://doi.org/10.1042/etls20230083

Gastrulation represents a pivotal phase of development and aberrations during this period can have major consequences, from minor anatomical deviations to severe congenital defects. Animal models are used to study gastrulation, however, there is cons... Read More about Interspecies control of development during mammalian gastrulation.

NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl (2023)
Journal Article
Simpson, L. A., Crowley, D., Forey, T., Acosta, H., Ferjentsik, Z., Chatfield, J., …Johnson, A. D. (2023). NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl. PLoS Biology, 21(6), Article e3002121. https://doi.org/10.1371/journal.pbio.3002121

Pluripotency defines the unlimited potential of individual cells of vertebrate embryos, from which all adult somatic cells and germ cells are derived. Understanding how the programming of pluripotency evolved has been obscured in part by a lack of da... Read More about NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl.