C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance

Malcolm, J.; Nyirenda, M. H.; Brown, J. L.; Adrados-Planell, A.; Campbell, L.; Butcher, J. P.; Glass, D. G.; Piela, K.; Goodyear, C. S.; Wright, A. J.; McInnes, I. B.; Millington, O. R.; Culshaw, S.

doi:10.1016/j.jaut.2023.102994

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C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance (2023)
Journal Article
Malcolm, J., Nyirenda, M. H., Brown, J. L., Adrados-Planell, A., Campbell, L., Butcher, J. P., …Culshaw, S. (2023). C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of Autoimmunity, 135, Article 102994. https://doi.org/10.1016/j.jaut.2023.102994

In rheumatoid arthritis, the emergence of anti-citrullinated autoimmunity is associated with HLA-antigen-T cell receptor complexes. The precise mechanisms underpinning this breach of tolerance are not well understood. Porphyromonas gingivalis express... Read More about C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance.