All Outputs (3)

In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans (2023)
Journal Article
Almutairi, F., Alyami, J., Pritchard, S., Alsharef, W., Spiller, R. C., Gowland, P. A., …Hoad, C. L. (2023). In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans. Clinical Nutrition Open Science, 51, 35-43. https://doi.org/10.1016/j.nutos.2023.08.002

The presence of a ‘magenstrasse’, a central ‘stomach road’ for flow and mixing of foods and drinks in the stomach had been predicted from hydrodynamic modelling. Here a magnetic resonance imaging (MRI) tagging technique was used to gain novel insight... Read More about In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans.

Stochastic Differential Equation-based Mixed Effects Model of the Fluid Volume in the Fasted Stomach in Healthy Adult Human (2023)
Journal Article
Wang, K., Marciani, L., Amidon, G. L., Smith, D. E., & Sun, D. (2023). Stochastic Differential Equation-based Mixed Effects Model of the Fluid Volume in the Fasted Stomach in Healthy Adult Human. AAPS Journal, 25(5), https://doi.org/10.1208/s12248-023-00840-3

The rate and extent of drug dissolution and absorption from a solid oral dosage form depend largely on the fluid volume along the gastrointestinal tract. Hence, a model built upon the gastric fluid volume profiles can help to predict drug dissolution... Read More about Stochastic Differential Equation-based Mixed Effects Model of the Fluid Volume in the Fasted Stomach in Healthy Adult Human.

MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time (2023)
Journal Article
Alshammari, M. T., Alyami, A. S., Wilkinson-Smith, V., Spiller, R. C., Gowland, P., Marciani, L., …Hoad, C. L. (2023). MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time. Neurogastroenterology and Motility, 35(8), Article e14610. https://doi.org/10.1111/nmo.14610

Background: Magnetic resonance imaging (MRI) tagging techniques have been applied to the GI tract to assess bowel contractions and content mixing. We aimed to evaluate the dependence of a tagging measurement (for assessing chyme mixing) on inter-obse... Read More about MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time.