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Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism (2024)
Journal Article
Beckett, L. J., Williams, P. M., Toh, L. S., Hessel, V., Gerstweiler, L., Fisk, I., Toronjo-Urquiza, L., & Chauhan, V. M. (2024). Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism. npj Microgravity, 10(1), Article 79. https://doi.org/10.1038/s41526-024-00418-z

Spaceflight presents significant challenges to the physiological state of living organisms. This can be due to the microgravity environment experienced during long-term space missions, resulting in alterations in muscle structure and function, such a... Read More about Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism.

Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years (2023)
Journal Article
Baamer, R. M., Humes, D. J., Toh, L. S., Knaggs, R. D., Lobo, D. N., Arabia, S., & Greenfield, D. (2023). Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years. BJS Open, 7(6), Article zrad136. https://doi.org/10.1093/bjsopen/zrad136

Background
While opioid analgesics are often necessary for the management of acute postoperative pain, appropriate prescribing practices are crucial to avoid harm. The aim was to investigate the changes in the proportion of people receiving initial... Read More about Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years.

Spaceflight Induces Strength Decline in Caenorhabditis elegans (2023)
Journal Article
Soni, P., Edwards, H., Anupom, T., Rahman, M., Lesanpezeshki, L., Blawzdziewicz, J., …Vanapalli, S. A. (2023). Spaceflight Induces Strength Decline in Caenorhabditis elegans. Cells, 12(20), Article 2470. https://doi.org/10.3390/cells12202470

Background: Understanding and countering the well-established negative health consequences of spaceflight remains a primary challenge preventing safe deep space exploration. Targeted/personalized therapeutics are at the forefront of space medicine st... Read More about Spaceflight Induces Strength Decline in Caenorhabditis elegans.

Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England (2023)
Journal Article
Baamer, R. M., Humes, D. J., Toh, L. S., Knaggs, R. D., & Lobo, D. N. (2023). Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England. Anaesthesia, 78(9), 1081-1092. https://doi.org/10.1111/anae.16055

This retrospective cohort study on adults undergoing colectomy from 2010 to 2019 used linked primary (Clinical Practice Research Datalink), and secondary (Hospital Episode Statistics) care data to determine the prevalence of persistent postoperative... Read More about Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England.

O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study (2023)
Presentation / Conference Contribution
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study. British Journal of Surgery, 110(Supplement 3), Article znad101.128. https://doi.org/10.1093/bjs/znad101.128

Introduction Opioid prescribing patterns after discharge following colectomy within a population from England are not well characterised. This study aimed to report changes in opioid prescribing prevalence, formulation choices and opioid analgesics o... Read More about O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study.

O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England (2023)
Presentation / Conference Contribution
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England. British Journal of Surgery, 110(Supplement 3), Article znad101.087. https://doi.org/10.1093/bjs/znad101.087

Introduction Little is known regarding whether opioid prescriptions following colectomy lead to persistent use. We aimed to determine the prevalence of persistent post-discharge opioid use following colectomy, stratified by preadmission opioid exposu... Read More about O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England.

Denosumab as a Pharmacological Countermeasure Against Osteopenia in Long Duration Spaceflight (2023)
Journal Article
Rengel, A. C., Tran, V., & Toh, L. S. (2023). Denosumab as a Pharmacological Countermeasure Against Osteopenia in Long Duration Spaceflight. Aerospace Medicine and Human Performance, 94(5), 389-395. https://doi.org/10.3357/AMHP.6053.2023

INTRODUCTION: Prolonged exposure to microgravity is associated with a significant reduction in bone density, exposing astronauts to renal calculi in flight and osteoporotic fractures on return to Earth. While physical countermeasures and bisphosphona... Read More about Denosumab as a Pharmacological Countermeasure Against Osteopenia in Long Duration Spaceflight.

Thai stakeholders’ awareness and perceptions of the patient adverse event reporting system for herbal medicines: a qualitative study (2023)
Journal Article
Worakunphanich, W., Suwankesawong, W., Youngkong, S., Thavorncharoensap, M., Anderson, C., & Toh, L. S. (2023). Thai stakeholders’ awareness and perceptions of the patient adverse event reporting system for herbal medicines: a qualitative study. International Journal of Clinical Pharmacy, 45(2), 491–501. https://doi.org/10.1007/s11096-022-01533-1

Background: In Thailand, the consumption of herbal medicines has been increasing. Adverse events (AEs) of herbal medicines have been identified through the spontaneous reporting system. However, the number of patients reporting AEs of herbal medicine... Read More about Thai stakeholders’ awareness and perceptions of the patient adverse event reporting system for herbal medicines: a qualitative study.

Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study (2022)
Journal Article
Anderson, C., Iqbal, A., Knaggs, R., & Toh, L. S. (2023). Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study. International Journal of Clinical Pharmacy, 45, 220-232. https://doi.org/10.1007/s11096-022-01493-6

Background Opioids are commonly used for the management of chronic non-malignant pain in Pakistan; but there is a lack of literature around precursors or motivators in the use of opioids.
Aim The study holistically explored factors contributing towa... Read More about Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study.

Anti-osteoporosis medication dispensing by clinical commissioning groups in England – an ecological study of variability in practice and of the effect of the Covid-19 pandemic (2022)
Journal Article
Toh, L. S., Johansen, A., Sami, A., Janjua, S. S., Boardman, H. F., Janjua, S. S., …Javaid, M. K. (2023). Anti-osteoporosis medication dispensing by clinical commissioning groups in England – an ecological study of variability in practice and of the effect of the Covid-19 pandemic. Pharmacoepidemiology and Drug Safety, 32(2), 248-255. https://doi.org/10.1002/pds.5544

Purpose: To investigate whether the rate of Anti-Osteoporosis Medication (AOM) dispensing was related to prevalence of risk factors and hip fracture incidence in the local population. Methods: The Open Prescribing database was used to analyse dispens... Read More about Anti-osteoporosis medication dispensing by clinical commissioning groups in England – an ecological study of variability in practice and of the effect of the Covid-19 pandemic.

Community health literacy outcome measurement practices: A scoping review of recent interventions (2022)
Journal Article
Sawyers, L., Anderson, C., Aslani, P., Duncan, G., Janjua, S. S., & Toh, L. S. (2022). Community health literacy outcome measurement practices: A scoping review of recent interventions. Health Science Reports, 5(5), Article e810. https://doi.org/10.1002/hsr2.810

Introduction: Evidence suggests that, while a preference for functional Health Literacy (HL) outcome measurement exists, researchers are converging towards more all-encompassing instruments. While this claim is present in the HL field, minimal resear... Read More about Community health literacy outcome measurement practices: A scoping review of recent interventions.

Routine omics collection is a golden opportunity for European human research in space and analog environments (2022)
Journal Article
Cope, H., Willis, C. R., MacKay, M. J., Rutter, L. A., Toh, L. S., Williams, P. M., …Szewczyk, N. J. (2022). Routine omics collection is a golden opportunity for European human research in space and analog environments. Patterns, 3(10), Article 100550. https://doi.org/10.1016/j.patter.2022.100550

Widespread generation and analysis of omics data have revolutionized molecular medicine on Earth, yet its power to yield new mechanistic insights and improve occupational health during spaceflight is still to be fully realized in humans. Nevertheless... Read More about Routine omics collection is a golden opportunity for European human research in space and analog environments.

Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance (2022)
Journal Article
Paskins, Z., Babatunde, O., Sturrock, A., Toh, L. S., Horne, R., Maidment, I., & on behalf of the Effectiveness Working Group of the Royal Osteoporosis Society Osteoporosis, Bone Research Academy. (2022). Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance. Osteoporosis International, https://doi.org/10.1007/s00198-022-06453-4

Summary: Systematic reviews that examine effectiveness of interventions to improve medicines optimisation do not explain how or why they work. This realist review identified that interventions which effectively optimise medicines use in osteoporosis... Read More about Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance.

Space Medicines for Space Health (2022)
Journal Article
Tran, Q. D., Tran, V., Toh, L. S., Williams, P. M., Tran, N. N., & Hessel, V. (2022). Space Medicines for Space Health. ACS Medicinal Chemistry Letters, 13(8), 1231–1247. https://doi.org/10.1021/acsmedchemlett.1c00681

Scientists from around the world are studying the effects of microgravity and cosmic radiation via the “off-Earth” International Space Station (ISS) laboratory platform. The ISS has helped scientists make discoveries that go beyond the basic understa... Read More about Space Medicines for Space Health.

Astropharmacy: Pushing the boundaries of the pharmacists’ role for sustainable space exploration (2022)
Journal Article
Sawyers, L., Anderson, C., Boyd, M. J., Hessel, V., Wotring, V., Williams, P. M., & Toh, L. S. (2022). Astropharmacy: Pushing the boundaries of the pharmacists’ role for sustainable space exploration. Research in Social and Administrative Pharmacy, https://doi.org/10.1016/j.sapharm.2022.02.002

Background: Human physiology undergoes extensive changes in space potentially leading to alterations in the way a medication functions. Understanding the efficacy behind Pharmacological Countermeasures (PCMs) and deliverable pharmacy services is impe... Read More about Astropharmacy: Pushing the boundaries of the pharmacists’ role for sustainable space exploration.

Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review (2022)
Journal Article
Baamer, R. M., Iqbal, A., Lobo, D. N., Knaggs, R. D., Levy, N. A., & Toh, L. S. (2022). Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review. British Journal of Anaesthesia, 128(5), 874-888. https://doi.org/10.1016/j.bja.2021.11.032

Background: We aimed to appraise the evidence relating to the measurement properties of unidimensional tools to quantify pain after surgery. Furthermore, we wished to identify the tools used to assess interference of pain with functional recovery. Me... Read More about Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review.

The association between incident vertebral deformities, health-related quality of life and functional impairment: a 10.7-year cohort study (2021)
Journal Article
Shah, A., Wu, F., Jones, G., Cicuttini, F., Toh, L., & Laslett, L. (2021). The association between incident vertebral deformities, health-related quality of life and functional impairment: a 10.7-year cohort study. Osteoporosis International, 32(11), 2247-2255. https://doi.org/10.1007/s00198-021-06004-3

We aimed to describe longitudinal changes in health-related quality of life (HRQoL) measures associated with incident vertebral deformities (VDs) over 10.7 years. Incident VDs are associated with clinically significant functional impairment in men, a... Read More about The association between incident vertebral deformities, health-related quality of life and functional impairment: a 10.7-year cohort study.

Awareness of osteoporosis risk assessment tools and screening recommendations among community pharmacists in Malaysia (2021)
Journal Article
Francis, J., Toh, L. S., Sellappans, R., & Loo, J. S. E. (2021). Awareness of osteoporosis risk assessment tools and screening recommendations among community pharmacists in Malaysia. International Journal of Clinical Pharmacy, 43(3), 604-612. https://doi.org/10.1007/s11096-020-01169-z

Background The incidence of osteoporosis in Malaysia is increasing due to a fast-ageing population. Because of its silent nature, various osteoporosis risk assessment tools exist to detect high-risk patients and facilitate referrals for bone mineral... Read More about Awareness of osteoporosis risk assessment tools and screening recommendations among community pharmacists in Malaysia.

Role of pharmacists in optimising opioid therapy for chronic non-malignant pain; A systematic review (2020)
Journal Article
Iqbal, A., Knaggs, R. D., Anderson, C., & Toh, L. S. (2022). Role of pharmacists in optimising opioid therapy for chronic non-malignant pain; A systematic review. Research in Social and Administrative Pharmacy, 18(3), 2352-2366. https://doi.org/10.1016/j.sapharm.2020.11.014

Background: Opioid optimisation is a global issue in Chronic Non-malignant Pain (CNMP) management. Objective: This systematic review aims to assess the effectiveness of interventions delivered by pharmacists in outpatient clinical settings, community... Read More about Role of pharmacists in optimising opioid therapy for chronic non-malignant pain; A systematic review.