All Outputs (2)

Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS (2024)
Journal Article
Lu, L., Kotowska, A. M., Kern, S., Fang, M., Rudd, T. R., Alexander, M. R., Scurr, D. J., & Zhu, Z. (2024). Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS. Analytical Chemistry, https://doi.org/10.1021/acs.analchem.4c01201

Growing clinical evidence reveals that systematic molecular alterations in the brain occur 20 years before the onset of AD pathological features. Apolipoprotein E4 (ApoE4) is one of the most significant genetic risk factors for Alzheimer’s disease (A... Read More about Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS.

Investigating ApoE4‐mediated metabolic alteration of H4 neuroglioma cells of Alzheimer’s disease
Presentation / Conference Contribution
Lu, L., Kotowska, A., Kern, S., Fang, M., Rudd, T. R., Alexander, M., Scurr, D., & Zhu, Z. Investigating ApoE4‐mediated metabolic alteration of H4 neuroglioma cells of Alzheimer’s disease. Presented at Alzheimer’s Association International Conference 2023, Amterdam, Netherlands and online

Background
Metabolites and proteins in ApoE4‐carried H4 neuroglioma cells were analyzed to investigate the potential mechanism of the risk gene ApoE4 involved in Alzheimer’s disease (AD).

Method
Metabolomics of ApoE4‐carried and wild‐type H4 cel... Read More about Investigating ApoE4‐mediated metabolic alteration of H4 neuroglioma cells of Alzheimer’s disease.