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Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function (2014)
Journal Article
Chen, L., Tang, W., Kowgier, M., Loth, D. W., Soler Artigas, M., Joubert, B. R., …Cassano, P. A. (2014). Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. PLoS ONE, 9(7), doi:10.1371/journal.pone.0100776. ISSN 1932-6203

Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. Methods: We performed GWAS of the rate of cha... Read More

Genome-wide association analysis identifies six new loci associated with forced vital capacity (2014)
Journal Article
Loth, D. W., Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., …London, S. J. (2014). Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nature Genetics, 46(7), doi:10.1038/ng.3011. ISSN 1061-4036

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies an... Read More