Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis
(2014)
Journal Article
Treude, F., Kappes, F., Fahrenkamp, D., Müller-Newen, G., Dajas-Bailador, F., Krämer, O. H., …Hartkamp, J. (2014). Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis. Oncotarget, 5(10), https://doi.org/10.18632/oncotarget.1634
The tumor suppressor protein prostate apoptosis response-4 (PAR-4) is silenced in a subset of human cancers and its down-regulation serves as a mechanism for cancer cell survival following chemotherapy. PAR-4 re-expression selectively causes apoptosi... Read More about Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis.