An internal ribosome entry site in the 5′ untranslated region of epidermal growth factor receptor allows hypoxic expression
(2015)
Journal Article
Webb, T. E., Hughes, A., Smalley, D., & Spriggs, K. (in press). An internal ribosome entry site in the 5′ untranslated region of epidermal growth factor receptor allows hypoxic expression. Oncogenesis, 4, Article e134. https://doi.org/10.1038/oncsis.2014.43
The expression of epidermal growth factor receptor (EGFR/ERBB1/HER1) is implicated in the progress of numerous cancers, a feature that has been exploited in the development of EGFR antibodies and EGFR tyrosine kinase inhibitors as anti-cancer drugs.... Read More about An internal ribosome entry site in the 5′ untranslated region of epidermal growth factor receptor allows hypoxic expression.