All Outputs (2)

Clinical comparison of alfaxalone, ketamine and propofol following medetomidine and methadone in dogs (2017)
Journal Article
White, K. L., & Yates, D. (in press). Clinical comparison of alfaxalone, ketamine and propofol following medetomidine and methadone in dogs. Veterinary Anaesthesia and Analgesia, https://doi.org/10.1016/j.vaa.2016.12.057

Objective

To compare the clinical effects of alfaxalone, ketamine and propofol in dogs following premedication with medetomidine and methadone.

Study design

Prospective, ‘blinded’ and randomized clinical study.

Animals

A total of 75 ma... Read More about Clinical comparison of alfaxalone, ketamine and propofol following medetomidine and methadone in dogs.

A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion (2017)
Journal Article
White, K. L., Paine, S., & Harris, J. (2017). A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion. Veterinary Anaesthesia and Analgesia, 44(4), https://doi.org/10.1016/j.vaa.2017.01.001

Objective: To characterise, as a clinical study, the pharmacokinetics and pharmacodynamics and describe the hypnotic effect of the neurosteroid alfaxalone (3α-hydroxy-5 α-pregnane-11, 20-dione) formulated with 2-hydroxypropyl-β-cyclodextrin in male a... Read More about A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion.