The antimalarial drug quinine interferes with serotonin biosynthesis and action
(2014)
Journal Article
Islahudin, F., Tindall, S. M., Mellor, I. R., Swift, K., Christensen, H. E., Fone, K. C., …Avery, S. V. (2014). The antimalarial drug quinine interferes with serotonin biosynthesis and action. Scientific Reports, 4(3618), https://doi.org/10.1038/srep03618
The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As... Read More about The antimalarial drug quinine interferes with serotonin biosynthesis and action.