All Outputs (3)

Genomic diversity of Helicobacter pylori populations from different regions of the human stomach (2022)
Journal Article
Wilkinson, D. J., Dickins, B., Robinson, K., & Winter, J. A. (2022). Genomic diversity of Helicobacter pylori populations from different regions of the human stomach. Gut Microbes, 14(1), Article 2152306. https://doi.org/10.1080/19490976.2022.2152306

Individuals infected with Helicobacter pylori harbor unique and diverse populations of quasispecies, but diversity between and within different regions of the human stomach and the process of bacterial adaptation to each location are not yet well und... Read More about Genomic diversity of Helicobacter pylori populations from different regions of the human stomach.

Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis (2022)
Journal Article
Southern, K. W., Castellani, C., Lammertyn, E., Smyth, A., VanDevanter, D., van Koningsbruggen-Rietschel, S., …Duff, A. (2023). Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis. Journal of Cystic Fibrosis, 22(1), 17-30. https://doi.org/10.1016/j.jcf.2022.10.002

Cystic fibrosis (CF) has entered the era of variant-specific therapy, tailored to the genetic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR modulators, the first variant-specific therapy available, have transfo... Read More about Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis.

The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa (2022)
Journal Article
Kaneko, K., Zaitoun, A. M., Letley, D. P., Rhead, J. L., Torres, J., Spendlove, I., …Robinson, K. (2022). The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa. Journal of Pathology, https://doi.org/10.1002/path.5990

High-level expression of decay-accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported. However, the role of Helicob... Read More about The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa.