All Outputs (4)

Gut reactions (2014)
Journal Article
Robinson, K. (2014). Gut reactions

A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach (2014)
Journal Article
Winter, J., Letley, D., Cook, K., Rhead, J., Zaitoun, A., Ingram, R., Amilon, K., Croxall, N., Kaye, P., Robinson, K., & Atherton, J. (2014). A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach. Journal of Infectious Diseases, 210(6), 954–963. https://doi.org/10.1093/infdis/jiu154

Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gastric adenocarcinoma. To our knowledge, we are the first to determine effects of different polymorphic forms of VacA on inflammation and... Read More about A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach.

CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa (2014)
Journal Article
Cook, K. W., Letley, D. P., Ingram, R. J., Staples, E., Skjoldmose, H., Atherton, J. C., & Robinson, K. (2014). CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa. Gut, 63(10), 1550-1559. https://doi.org/10.1136/gutjnl-2013-306253

Background Helicobacter pylori-induced peptic ulceration is less likely to occur in patients with a strong gastric anti-inflammatory regulatory T cell (Treg) response. Migration of Tregs into the gastric mucosa is therefore important.

Objective To... Read More about CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa.

Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells (2014)
Journal Article
Winter, J., Letley, D., Rhead, J., Atherton, J., & Robinson, K. (2014). Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells. Infection and Immunity, 82(4), 1372-1381. https://doi.org/10.1128/iai.01443-13

Persistent Helicobacter pylori infection induces chronic inflammation in the human gastric mucosa, which is associated with development of peptic ulceration, gastric atrophy, and gastric adenocarcinoma. It has been postulated that secretion of immuno... Read More about Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells.