Structural flexibility of a conserved antigenic region in Hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies

Meola, Annalisa; Tarr, Alexander V.; England, Patrick; Meredith, Luke W.; McClure, Patrick; Foung, Steven K.H.; McKeating, Jane A.; Ball, Jonathan K.; Rey, Felix A.; Krey, Thomas

doi:10.1128/JVI.02190-14

All Outputs (3)

An ancestral host defence peptide within human beta-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule (2015)
Journal Article

Host defence peptides (HDPs) are critical components of innate immunity. Despite their diversity, they share common features including a structural signature, designated “γ-core motif”. We reasoned that for each HDPs evolved from an ancestral γ-core,... Read More about An ancestral host defence peptide within human beta-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule.

Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces (2015)
Journal Article

© 2015 Elsevier B.V. Phage-displayed random peptide libraries are widely used for identifying peptide interactions with proteins and other substrates. Selection of peptide ligands involves iterative rounds of affinity enrichment. The binding properti... Read More about Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces.

Structural flexibility of a conserved antigenic region in Hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies (2015)
Journal Article

Neutralizing antibodies (NAbs) targeting glycoprotein E2 are important for the control of hepatitis C virus (HCV) infection. One conserved antigenic site (amino acids 412 to 423) is disordered in the reported E2 structure, but a synthetic peptide mim... Read More about Structural flexibility of a conserved antigenic region in Hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies.