All Outputs (34)

Tuning the conformation of synthetic co-polypeptides of serine and glutamic acid through control over polymer composition (2016)
Journal Article

Ring opening polymerization (ROP) of N‐carboxy anhydride (NCA) amino acids presents a rapid way to synthesize high molecular weight polypeptides with different amino acid compositions. The compositional and functional versatility of polypeptides make... Read More about Tuning the conformation of synthetic co-polypeptides of serine and glutamic acid through control over polymer composition.

Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release (2016)
Journal Article
Wren, S. A. C., Aylott, J. W., Tres, F., Treacher, K., Booth, J., Hughes, L. P., …Burley, J. C. (2016). Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release. Molecular Pharmaceutics, 13(3), 1166-1175. https://doi.org/10.1021/acs.molpharmaceut.5b00979

© 2016 American Chemical Society. Because of its weakly acidic nature (pKa of 4.5), indomethacin presents an aqueous solubility that significantly increases when changing from acidic to neutral/alkaline pH (1.5 μg/mL at pH 1.2 and 105.2 μg/mL at pH 7... Read More about Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release.

Investigating NF-kappa B signaling in lung fibroblasts in 2D and 3D culture systems (2015)
Journal Article

Controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells using porphyrin conjugated nanoparticles (2015)
Journal Article
Lavado, A. S., Chauhan, V. M., Alhaj Zen, A., Giuntini, F., Jones, D. R. E., Boyle, R. W., …Aylott, J. W. (2015). Controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells using porphyrin conjugated nanoparticles. Nanoscale, 7(34), https://doi.org/10.1039/c5nr00795j

Nanoparticles capable of generating controlled amounts of intracellular reactive oxygen species (ROS), that advance the study of oxidative stress and cellular communication, were synthesized by functionalizing polyacrylamide nanoparticles with zinc(I... Read More about Controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells using porphyrin conjugated nanoparticles.

Investigating the dissolution performance of amorphous solid dispersions using magnetic resonance imaging and proton NMR (2015)
Journal Article
Tres, F., Coombes, S. R., Phillips, A. R., Hughes, L. P., Wren, S. A., Aylott, J., & Burley, J. (2015). Investigating the dissolution performance of amorphous solid dispersions using magnetic resonance imaging and proton NMR. Molecules, 20(9), 16404-16418. https://doi.org/10.3390/molecules200916404

Facile approach to generating polymeric nanoarrays containing populations of nanoparticles (2015)
Journal Article

The production of nanoarrays containing a population of entrapped, heterogeneous nanoparticles is reported. The nanoarray consists of a nanoporous film with pores of diameter 60-180 nm, formed from the phase separation of two immiscible polymers: pol... Read More about Facile approach to generating polymeric nanoarrays containing populations of nanoparticles.

Adapting the electrospinning process to provide three unique environments for a tri-layered in vitro model of the airway wall (2015)
Journal Article

Electrospinning is a highly adaptable method producing porous 3D fibrous scaffolds that can be exploited in in vitro cell culture. Alterations to intrinsic parameters within the process allow a high degree of control over scaffold characteristics inc... Read More about Adapting the electrospinning process to provide three unique environments for a tri-layered in vitro model of the airway wall.

Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping (2015)
Journal Article

Real-time in situ Raman mapping has been employed to monitor, during dissolution, the crystallization transitions of amorphous bicalutamide formulated as a molecular dispersion in a copovidone VA64 matrix. The dissolution performance was also investi... Read More about Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping.

An appraisal of the Suzuki cross-coupling reaction for the synthesis of novel fluorescent coumarin derivatives (2014)
Journal Article
Alhaj Zen, A., Aylott, J. W., & Chan, W. C. (2014). An appraisal of the Suzuki cross-coupling reaction for the synthesis of novel fluorescent coumarin derivatives. Tetrahedron Letters, 55(40), https://doi.org/10.1016/j.tetlet.2014.08.058

We report the chemical design and development of 3-aryl-substituted 7-alkoxy-4-methylcoumarins with enhanced fluorogenic properties. The 3-aryl substituents are installed via an optimized Suzuki–Miyaura cross-coupling (SMC) reaction between a 7-alkox... Read More about An appraisal of the Suzuki cross-coupling reaction for the synthesis of novel fluorescent coumarin derivatives.

Utilizing nanosensor-incorporated scaffolds in the development of a 3D lung model (2014)
Book Chapter
Harrington, H. C., Rose, F. R., Ghaemmaghami, A. M., & Aylott, J. W. (2014). Utilizing nanosensor-incorporated scaffolds in the development of a 3D lung model. In J. Haycock, A. Ahluwalia, & J. M. Wilkinson (Eds.), Cellular In Vitro Testing (89-107). Jenny Stanford Publishing

Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds (2014)
Journal Article
Morris, G., Bridge, J., Eltboli, O., Lewis, M., Knox, A., Aylott, J. W., …Rose, F. R. (2014). Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds. AJP - Lung Cellular and Molecular Physiology, 307(1), Article L38-L47. https://doi.org/10.1152/ajplung.00318.2013

Human airway smooth muscle (HASM) contraction plays a central role in regulating airway resistance in both healthy and asthmatic bronchioles. In vitro studies that investigate the intricate mechanisms that regulate this contractile process are predom... Read More about Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.

Real time Raman imaging to understand dissolution performance of amorphous solid dispersions (2014)
Journal Article
Tres, F., Treacher, K., Booth, J., Hughes, L. P., Wren, S. A., Aylott, J. W., & Burley, J. C. (2014). Real time Raman imaging to understand dissolution performance of amorphous solid dispersions. Journal of Controlled Release, 188, https://doi.org/10.1016/j.jconrel.2014.05.061

We have employed for the first time Raman spectroscopic imaging along with multi-variate curve resolution (MCR) analysis to investigate in real time and in-situ the dissolution mechanisms that underpin amorphous solid dispersions, with data being col... Read More about Real time Raman imaging to understand dissolution performance of amorphous solid dispersions.

Fluorescent nanosensors for intracellular measurements: synthesis, characterization, calibration, and measurement (2014)
Journal Article

CHOTs optical transducers (2011)
Journal Article
Arca, A., Aylott, J., Marques, L., Clark, M., Somekh, M., Smith, R., …Chen, X. (2011). CHOTs optical transducers. Nondestructive Testing and Evaluation, 26(3-4), 353-366. https://doi.org/10.1080/10589759.2011.573555

Laser ultrasonics conventionally use direct absorption in the sample to generate ultrasound and monitor the sample to detect the ultrasound. However, in some circumstances there are significant advantages to using an optical transducer - a device to... Read More about CHOTs optical transducers.