Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation
(2017)
Journal Article
Ivanov, I., Matafonov, A., Sun, M., Cheng, Q., Dickeson, S. K., Verhamme, I. M., …Gailani, D. (2017). Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation. Blood, 129(11), 1527-1537. https://doi.org/10.1182/blood-2016-10-744110
When blood is exposed to variety of artificial surfaces and biologic substances, the plasma proteins factor XII (FXII) and prekallikrein undergo reciprocal proteolytic conversion to the proteases αFXIIa and α-kallikrein by a process called contact ac... Read More about Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation.