All Outputs (3)

Exploiting the kinetic interplay between GPIb -VWF binding interfaces to regulate hemostasis and thrombosis (2014)
Journal Article
Chen, J., Zhou, H., Diacovo, A., Zheng, X. L., Emsley, J., & Diacovo, T. G. (2014). Exploiting the kinetic interplay between GPIb -VWF binding interfaces to regulate hemostasis and thrombosis. Blood, 124(25), https://doi.org/10.1182/blood-2014-04-569392

Platelet–von Willebrand factor (VWF) interactions must be tightly regulated in order to promote effective hemostasis and prevent occlusive thrombus formation. However, it is unclear what role the inherent properties of the bond formed between the pla... Read More about Exploiting the kinetic interplay between GPIb -VWF binding interfaces to regulate hemostasis and thrombosis.

Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains (2014)
Journal Article
Harper, S., Gratton, H. E., Cornaciu, I., Oberer, M., Scott, D. J., Emsley, J., & Dreveny, I. (2014). Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains. Biochemistry, 53(18), 2966-2978. https://doi.org/10.1021/bi500116x

The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replication, and TGFβ signaling. We report the first characterization of the USP11 domain architecture and its role in regulating the enzymatic activity. USP11 consists... Read More about Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains.

The mechanism underlying activation of factor IX by factor XIa (2014)
Journal Article
Gailani, D., Geng, Y., Verhamme, I., Sun, M.-F., Bajaj, S. P., Messer, A., & Emsley, J. (2014). The mechanism underlying activation of factor IX by factor XIa. Thrombosis Research, 133(Supplement 1), S48-S51. https://doi.org/10.1016/j.thromres.2014.03.020

Factor XI (fXI) is the zymogen of a plasma protease, factor XIa (fXIa), that contributes to thrombin generation during blood coagulation by proteolytic conversion of factor IX (fIX) to factor IXaβ (fIXaβ). There is considerable interest in fXIa as a... Read More about The mechanism underlying activation of factor IX by factor XIa.