All Outputs (53)

The Hele-Shaw injection problem for an extremely shear-thinning fluid (2015)
Journal Article

We consider Hele-Shaw flows driven by injection of a highly shear-thinning power-law fluid (of exponent n) in the absence of surface tension. We formulate the problem in terms of the streamfunction ψ, which satisfies the p-Laplacian equation ∇·(|∇ψ|p... Read More about The Hele-Shaw injection problem for an extremely shear-thinning fluid.

FlowerNet: a gene expression correlation metwork for anther and pollen development (2015)
Journal Article
Pearce, S., Ferguson, A., King, J., & Wilson, Z. A. (2015). FlowerNet: a gene expression correlation metwork for anther and pollen development. Plant Physiology, 167(4), https://doi.org/10.1104/pp.114.253807

Floral formation, in particular anther and pollen development, is a complex biological process with critical importance for seed set and for targeted plant breeding. Many key transcription factors regulating this process have been identified; however... Read More about FlowerNet: a gene expression correlation metwork for anther and pollen development.

Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6 (2015)
Journal Article
Mendiondo, G. M., Gibbs, D. J., Szurman-Zubrzycka, M., Korn, A., Marquez, J., Szarejko, I., …Holdsworth, M. J. (2016). Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6. Plant Biotechnology Journal, 14(1), 40-50. https://doi.org/10.1111/pbi.12334

© 2016 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd. Increased tolerance of crops to low oxygen (hypoxia) during flooding is a key target for food security. In Arabidopsis thaliana (L.) Heynh., the N... Read More about Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6.

A mathematical model of the human metabolic system and metabolic flexibility (2014)
Journal Article
Pearson, T., Wattis, J. A., King, J. R., MacDonald, I. A., & Mazzatti, D. (2014). A mathematical model of the human metabolic system and metabolic flexibility. Bulletin of Mathematical Biology, 76(9), https://doi.org/10.1007/s11538-014-0001-4

In healthy subjects some tissues in the human body display metabolic flexibility, by this we mean the ability for the tissue to switch its fuel source between predominantly carbohydrates in the post prandial state and predominantly fats in the fasted... Read More about A mathematical model of the human metabolic system and metabolic flexibility.

Systems Analysis of Auxin Transport in the Arabidopsis Root Apex (2014)
Journal Article
Band, L. R., Wells, D. M., Fozard, J. A., Ghetiu, T., French, A. P., Pound, M. P., …Bennett, M. J. (2014). Systems Analysis of Auxin Transport in the Arabidopsis Root Apex. Plant Cell, 26(3), 862-875. https://doi.org/10.1105/tpc.113.119495

Auxin is a key regulator of plant growth and development. Within the root tip, auxin distribution plays a crucial role specifying developmental zones and coordinating tropic responses. Determining how the organ-scale auxin pattern is regulated at the... Read More about Systems Analysis of Auxin Transport in the Arabidopsis Root Apex.

Vertex-element models for anisotropic growth of elongated plant organs (2013)
Journal Article
Fozard, J. A., Lucas, M., King, J. R., & Jensen, O. E. (2013). Vertex-element models for anisotropic growth of elongated plant organs. Frontiers in Plant Science, 4(233), https://doi.org/10.3389/fpls.2013.00233

New tools are required to address the challenge of relating plant hormone levels, hormone responses, wall biochemistry and wall mechanical properties to organ-scale growth. Current vertex-based models (applied in other contexts) can be unsuitable for... Read More about Vertex-element models for anisotropic growth of elongated plant organs.

The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum (2013)
Journal Article
Jabbari, S., Steiner, E., Heap, J. T., Winzer, K., Minton, N. P., & King, J. R. (2013). The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum. Mathematical Biosciences, 243(2), https://doi.org/10.1016/j.mbs.2013.03.005

The bacterium Clostridium acetobutylicum produces acids as an energy-yielding process during exponential growth. An acidic environment, however, is toxic to the cells and two survival mechanisms are in place to prevent them from dying. Firstly, durin... Read More about The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum.

Continuum limits of pattern formation in hexagonal-cell monolayers (2012)
Journal Article
O'Dea, R. D., & King, J. R. (2012). Continuum limits of pattern formation in hexagonal-cell monolayers. Journal of Mathematical Biology, 64(3), https://doi.org/10.1007/s00285-011-0427-3

Intercellular signalling is key in determining cell fate. In closely packed tissues such as epithelia, juxtacrine signalling is thought to be a mechanism for the generation of fine-grained spatial patterns in cell differentiation commonly observed in... Read More about Continuum limits of pattern formation in hexagonal-cell monolayers.

The isolation of spatial patterning modes in a mathematical model of juxtacrine cell signalling (2011)
Journal Article
O'Dea, R. D., & King, J. R. (2013). The isolation of spatial patterning modes in a mathematical model of juxtacrine cell signalling. Mathematical Medicine and Biology, 30(2), https://doi.org/10.1093/imammb/dqr028

Juxtacrine signalling mechanisms are known to be crucial in tissue and organ development, leading to spatial patterns in gene expression. We investigate the patterning behaviour of a discrete model of juxtacrine cell signalling due to Owen \& Sherrat... Read More about The isolation of spatial patterning modes in a mathematical model of juxtacrine cell signalling.

Multiscale analysis of pattern formation via intercellular signalling (2011)
Journal Article
O'Dea, R. D., & King, J. R. (2011). Multiscale analysis of pattern formation via intercellular signalling. Mathematical Biosciences, 231(2), https://doi.org/10.1016/j.mbs.2011.03.003

Lateral inhibition, a juxtacrine signalling mechanism by which a cell adopting a particular fate inhibits neighbouring cells from doing likewise, has been shown to be a robust mechanism for the formation of fine-grained spatial patterns (in which adj... Read More about Multiscale analysis of pattern formation via intercellular signalling.

Stochastic and deterministic multiscale models for systems biology: An auxin-transport case study (2010)
Journal Article
Twycross, J., Band, L. R., Bennett, M. J., King, J. R., & Krasnogor, N. (2010). Stochastic and deterministic multiscale models for systems biology: An auxin-transport case study. BMC Systems Biology, 4, https://doi.org/10.1186/1752-0509-4-34

Background: Stochastic and asymptotic methods are powerful tools in developing multiscale systems biology models; however, little has been done in this context to compare the efficacy of these methods. The majority of current systems biology modellin... Read More about Stochastic and deterministic multiscale models for systems biology: An auxin-transport case study.

A multiple timescale analysis of a mathematical model of the Wnt/β-catenin signalling pathway (2009)
Journal Article
Mirams, G. R., Byrne, H. M., & King, J. R. (2010). A multiple timescale analysis of a mathematical model of the Wnt/β-catenin signalling pathway. Journal of Mathematical Biology, 60(1), 131-160. https://doi.org/10.1007/s00285-009-0262-y

The Wnt signalling pathway is involved in stem cell maintenance, differentiation and tissue development. Its disregulation has also been implicated in many cancers. β-catenin is a protein that regulates both transcription of many genes and cell-cell... Read More about A multiple timescale analysis of a mathematical model of the Wnt/β-catenin signalling pathway.

Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells (2007)
Journal Article
van Leeuwen, I. M. M., Byrne, H. M., Jensen, O. E., & King, J. R. (2007). Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells. Journal of Theoretical Biology, 247(1), 77-102. https://doi.org/10.1016/j.jtbi.2007.01.019

Wnt signalling is involved in a wide range of physiological and pathological processes. The presence of an extracellular Wnt stimulus induces cytoplasmic stabilisation and nuclear translocation of beta-catenin, a protein that also plays an essential... Read More about Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells.