All Outputs (14)

Methodology for Digital Transformation: A Continuous Improvement Approach (2023)
Presentation / Conference Contribution
Hernández Oliver, K., Martínez-Arellano, G., & Segal, J. (2023). Methodology for Digital Transformation: A Continuous Improvement Approach. In 1st Workshop on Low-Cost Digital Solutions for Industrial Automation

Digital technologies have the potential to significantly transform the manufacturing industry by achieving improvements in productivity, quality and sustainability. Despite this, the uptake is relatively low as companies face a number of challenges i... Read More about Methodology for Digital Transformation: A Continuous Improvement Approach.

Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study (2023)
Presentation / Conference Contribution
Hernández Oliver, K. H., Martínez-Arellano, G., & Segal, J. (2023). Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study. In 1st Workshop on Low-Cost Digital Solutions for Industrial Automation

The use of digital technologies around the world has increased considerably, modifying the way in which daily activities are conducted. The manufacturing sector is no exception. Over the last decade, digital technologies have become a key element for... Read More about Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study.

Development of a Cubesat Platform for Biomedical and Pharmaceutical LEO Experiments (2020)
Presentation / Conference Contribution
Robson, D., Cappelletti, C., Segal, J., Williams, P., & Szewczyk, N. (2020). Development of a Cubesat Platform for Biomedical and Pharmaceutical LEO Experiments. In Advances in the Astronautical Sciences Fifth IAA Conference on University Satellite Missions and CubeSat Workshop 2020 (189-196)

Undertaking biology experiments in space is a necessary and important part of understanding evolution, adaption, and ageing, and crucial to the enablement of safe human exploration away from Earth. Access to space, however, is difficult, costly and r... Read More about Development of a Cubesat Platform for Biomedical and Pharmaceutical LEO Experiments.

Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules (2020)
Journal Article
Sabri, A., Ogilvie, J., McKenna, J., Segal, J., Scurr, D., & Marlow, M. (2020). Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules. Molecular Pharmaceutics, 17(8), 2925–2937. https://doi.org/10.1021/acs.molpharmaceut.0c00347

Basal cell carcinoma (BCC) is the most common cutaneous malignancy in humans. One of the most efficacious drugs used in the management of BCC is the immunomodulator, imiquimod. However, imiquimod has physiochemical properties that limit its permeatio... Read More about Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules.

Characterisation of mechanical insertion of commercial microneedles (2020)
Journal Article
Sabri, A. H., Cater, Z., Ogilvie, J., Scurr, D. J., Marlow, M., & Segal, J. (2020). Characterisation of mechanical insertion of commercial microneedles. Journal of Drug Delivery Science and Technology, 58, Article 101766. https://doi.org/10.1016/j.jddst.2020.101766

The protection provided by the human skin is mostly attributed to the stratum corneum. However, this barrier also limits the range of molecules that can be delivered into and across the skin. One of the methods to overcome this physiological barrier... Read More about Characterisation of mechanical insertion of commercial microneedles.

The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells (2020)
Journal Article
Ruiter, F. A., Sidney, L. E., Kiick, K. L., Segal, J. I., Alexander, C., & Rose, F. R. A. J. (2020). The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells. Biomaterials Science, 8(9), 2611-2626. https://doi.org/10.1039/c9bm01965k

Current cell expansion methods for tissue engineering and regenerative medicine applications rely on the use of enzymatic digestion passaging and 2D platforms. However, this enzymatic treatment significantly reduces cell quality, due to the destructi... Read More about The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells.

Improving children’s and their visitors’ hand hygiene compliance (2019)
Journal Article
Lary, D., Calvert, A., Nerlich, B., Segal, J., Vaughan, N., Randle, J., & Hardie, K. (2020). Improving children’s and their visitors’ hand hygiene compliance. Journal of Infection Prevention, 21(2), 60-67. https://doi.org/10.1177/1757177419892065

Background: Numerous interventions have tried to improve healthcare workers' hand hygiene compliance, however little attention has been paid to children's and their visitors’ compliance. Aim: To increase children’s and visitors’ compliance using in... Read More about Improving children’s and their visitors’ hand hygiene compliance.

Self-assembling benzothiazole-based gelators: a mechanistic understanding of in vitro bioactivation and gelation (2018)
Journal Article
Citossi, F., Smith, T., Lee, J. B., Segal, J., Gershkovich, P., Stocks, M. J., …Marlow, M. (in press). Self-assembling benzothiazole-based gelators: a mechanistic understanding of in vitro bioactivation and gelation. Molecular Pharmaceutics, 15(4), https://doi.org/10.1021/acs.molpharmaceut.7b01106

Low molecular weight gelators (LMWGs) of chemotherapeutic drugs represent a valid alternative to the existing poly-mer-based formulations used for targeted delivery of anticancer drugs. Herein we report the design and development of novel self-assemb... Read More about Self-assembling benzothiazole-based gelators: a mechanistic understanding of in vitro bioactivation and gelation.

A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies (2017)
Journal Article
Ruiter, F. A. A., Alexander, C., Rose, F. R., & Segal, J. (2017). A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies. Biomedical Materials, 12(5), Article 055009. https://doi.org/10.1088/1748-605X/aa7b54

Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple... Read More about A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies.

Cyclic pressure on compression-moulded bioresorbable phosphate glass fibre reinforced composites (2016)
Journal Article
Barrera Betanzos, F., Gimeno-Fabra, M., Segal, J., Grant, D., & Ahmed, I. (2016). Cyclic pressure on compression-moulded bioresorbable phosphate glass fibre reinforced composites. Materials and Design, 100, https://doi.org/10.1016/j.matdes.2016.03.108

The use of thermoplastic composites based on poly(lactic) acid and phosphate glass fibres over metallic alloys for clinical restorative treatment is highly beneficial due to their biocompatibility and biodegradability. However, difficulties in achiev... Read More about Cyclic pressure on compression-moulded bioresorbable phosphate glass fibre reinforced composites.

A decision support methodology for embodiment design and process chain selection for hybrid manufacturing platforms (2016)
Journal Article

This paper presents a methodology for the transformation of a product concept into a detailed design and manufacturing process chain for hybrid manufacturing platforms. Hybrid platforms offer new capabilities and opportunities for product design. How... Read More about A decision support methodology for embodiment design and process chain selection for hybrid manufacturing platforms.

A 3D bioprinting exemplar of the consequences of the regulatory requirements on customized processes (2015)
Journal Article

Computer-aided 3D printing approaches to the industrial production of customized 3D functional living constructs for restoration of tissue and organ function face significant regulatory challenges. Using the manufacture of a customized, 3D-bioprinted... Read More about A 3D bioprinting exemplar of the consequences of the regulatory requirements on customized processes.

Preferential sputtering in phosphate glass systems for the processing of bioactive coatings (2015)
Journal Article

Improving umbilical cord blood processing to increase total nucleated cell count yield and reduce cord input wastage by managing the consequences of input variation (2014)
Journal Article

Background aims: With the rising use of umbilical cord blood (UCB) as an alternative source of hematopoietic stem cells, storage inventories of UCB have grown, giving rise to genetically diverse inventories globally. In the absence of reliable marker... Read More about Improving umbilical cord blood processing to increase total nucleated cell count yield and reduce cord input wastage by managing the consequences of input variation.