All Outputs (2)

Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate (2016)
Journal Article
Eltaher, H. M., Yang, J., Shakesheff, K. M., & Dixon, J. E. (2016). Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate. Acta Biomaterialia, 41, 181-192. https://doi.org/10.1016/j.actbio.2016.06.004

Fundamental behaviour such as cell fate, growth and death are mediated through the control of key genetic transcriptional regulators. These regulators are activated or repressed by the integration of multiple signalling molecules in spatio-temporal g... Read More about Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate.

Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides (2016)
Journal Article
Dixon, J. E., Osman, G., Morris, G. E., Markides, H., Rotherham, M., Bayoussef, Z., …Shakesheff, K. M. (2016). Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides. Proceedings of the National Academy of Sciences, 113(3), E291-E299. https://doi.org/10.1073/pnas.1518634113

Protein transduction domains (PTDs) are powerful nongenetic tools that allow intracellular delivery of conjugated cargoes to modify cell behavior. Their use in biomedicine has been hampered by inefficient delivery to nuclear and cytoplasmic targets.... Read More about Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides.