Phenotypic and functional translation of IL33 genetics in asthma

Ketelaar, Maria E.; Portelli, Michael A.; Dijk, F. Nicole; Shrine, Nick; Faiz, Alen; Vermeulen, Cornelis J.; Xu, Cheng J.; Hankinson, Jenny; Bhaker, Sangita; Henry, Amanda P.; Billington, Charlote K.; Shaw, Dominick E.; Johnson, Simon R.; Benest, Andrew; Pang, Vincent; Bates, David O.; Pogson, Zara E.K.; Fogarty, Andrew; McKeever, Tricia M.; Singapuri, Amisha; Heaney, Liam G.; Mansur, Adel H.; Chaudhuri, Rekha; Thomson, Neil C.; Holloway, John W.; Lockett, Gabrielle A.; Howarth, Peter H.; Niven, Robert; Simpson, Angela; Tobin, Martin D.; Hall, Ian P.; Wain, Louise V.; Blakey, John D.; Brightling, Christopher E.; Obeidat, Ma'en; Sin, Don D.; Nickle, David C.; Boss�, Yohan; Vonk, Judith M.; van den Berge, Maarten; Koppelman, Gerard H.; Sayers, Ian; Nawijn, Martijn C.

doi:10.1016/j.jaci.2020.04.051

All Outputs (2)

Epithelial cell dysfunction, a major driver of asthma development (2020)
Journal Article

Airway epithelial barrier dysfunction is frequently observed in asthma and may have important implications. The physical barrier function of the airway epithelium is tightly interwoven with its immunomodulatory actions, while abnormal epithelial repa... Read More about Epithelial cell dysfunction, a major driver of asthma development.

Phenotypic and functional translation of IL33 genetics in asthma (2020)
Journal Article
Ketelaar, M. E., Portelli, M. A., Dijk, F. N., Shrine, N., Faiz, A., Vermeulen, C. J., …Nawijn, M. C. (2021). Phenotypic and functional translation of IL33 genetics in asthma. Journal of Allergy and Clinical Immunology, 147(1), 144-157. https://doi.org/10.1016/j.jaci.2020.04.051

© 2020 Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevate... Read More about Phenotypic and functional translation of IL33 genetics in asthma.