Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis

Guillen-Guio, Beatriz; Paynton, Megan L.; Allen, Richard J.; Chin, Daniel P.W.; Donoghue, Lauren J.; Stockwell, Amy; Leavy, Olivia C.; Hernandez-Beeftink, Tamara; Reynolds, Carl; Cullinan, Paul; Martinez, Fernando; Booth, Helen L.; Fahy, William A.; Hall, Ian P.; Hart, Simon P.; Hill, Mike R.; Hirani, Nik; Hubbard, Richard B.; McAnulty, Robin J.; Millar, Ann B.; Navaratnam, Vidya; Oballa, Eunice; Parfrey, Helen; Saini, Gauri; Sayers, Ian; Tobin, Martin D.; Whyte, Moira K. B.; Adegunsoye, Ayodeji; Kaminski, Naftali; Ma, Shwu Fan; Strek, Mary E.; Zhang, Yingze; Fingerlin, Tasha E.; Molina-Molina, Maria; Neighbors, Margaret; Sheng, X. Rebecca; Oldham, Justin M.; Maher, Toby M.; Molyneaux, Philip L.; Flores, Carlos; Noth, Imre; Schwartz, David A.; Yaspan, Brian L.; Jenkins, R. Gisli; Wain, Louise V.; Hollox, Edward J.

doi:10.1183/23120541.00553-2023

All Outputs (4)

Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk (2023)
Journal Article
Shrine, N., Izquierdo, A. G., Chen, J., Packer, R., Hall, R. J., Guyatt, A. L., …Consortium Lead Principal Investigators. (2023). Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Nature Genetics, 55, 1778–1779. https://doi.org/10.1038/s41588-023-01531-7

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection (2023)
Journal Article
Packer, R. J., Shrine, N., Hall, R., Melbourne, C. A., Thompson, R., Williams, A. T., …Wain, L. V. (2023). Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection. European Respiratory Journal, 61(6), Article 2201667. https://doi.org/10.1183/13993003.01667-2022

Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve understanding of its cause... Read More about Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk (2023)
Journal Article
Shrine, N., Izquierdo, A. G., Chen, J., Packer, R., Hall, R. J., Guyatt, A. L., …The Qatar Genome Program Research (QGPR) Consortium. (2023). Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Nature Genetics, 55(3), 410-422. https://doi.org/10.1038/s41588-023-01314-0

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020... Read More about Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.

Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis (2023)
Journal Article
Guillen-Guio, B., Paynton, M. L., Allen, R. J., Chin, D. P., Donoghue, L. J., Stockwell, A., …Hollox, E. J. (2024). Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis. ERJ Open Research, 10(1), 00553-2023. https://doi.org/10.1183/23120541.00553-2023

Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF, and a prior ass... Read More about Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis.