Genetic Associations and Architecture of Asthma-COPD Overlap

John, Catherine; Guyatt, Anna L.; Shrine, Nick; Packer, Richard; Olafsdottir, Thorunn A.; Liu, Jiangyuan; Hayden, Lystra P.; Chu, Su H.; Koskela, Jukka T.; Luan, Jian’an; Li, Xingnan; Terzikhan, Natalie; Xu, Hanfei; Bartz, Traci M.; Petersen, Hans; Leng, Shuguang; Belinsky, Steven A.; Cepelis, Aivaras; Hernández Cordero, Ana I.; Obeidat, Ma’en; Thorleifsson, Gudmar; Meyers, Deborah A.; Bleecker, Eugene R.; Sakoda, Lori C.; Iribarren, Carlos; Tesfaigzi, Yohannes; Gharib, Sina A.; Dupuis, Josée; Brusselle, Guy; Lahousse, Lies; Ortega, Victor E.; Jonsdottir, Ingileif; Sin, Don D.; Bossé, Yohan; van den Berge, Maarten; Nickle, David; Quint, Jennifer K.; Sayers, Ian; Hall, Ian P.; Langenberg, Claudia; Ripatti, Samuli; Laitinen, Tarja; Wu, Ann C.; Lasky-Su, Jessica; Bakke, Per; Gulsvik, Amund; Hersh, Craig P.; Hayward, Caroline; Langhammer, Arnulf; Brumpton, Ben; Stefansson, Kari; Cho, Michael H.; Wain, Louise V.; Tobin, Martin D.

doi:10.1016/j.chest.2021.12.674

All Outputs (3)

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank (2022)
Journal Article
Fawcett, K. A., Demidov, G., Shrine, N., Paynton, M. L., Ossowski, S., Sayers, I., …Hollox, E. J. (2022). Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank. BMC Medical Genomics, 15, Article 119. https://doi.org/10.1186/s12920-022-01268-y

Background The role of copy number variants (CNVs) in susceptibility to asthma is not well understood. This is, in part, due to the difficulty of accurately measuring CNVs in large enough sample sizes to detect associations. The recent availability... Read More about Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank.

Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease (2022)
Journal Article
Guyatt, A., John, C., Williams, A. T., Shrine, N., Reeve, N. F., Sayers, I., …SpiroMeta consortium. (2023). Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease. Thorax, 78(5), 496-503. https://doi.org/10.1136/thoraxjnl-2021-217993

Rationale Eosinophils are associated with airway inflammation in respiratory disease. Eosinophil production and survival is controlled partly by interleukin-5: anti-interleukin-5 agents reduce asthma and response correlates with baseline eosinophil c... Read More about Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease.

Genetic Associations and Architecture of Asthma-COPD Overlap (2022)
Journal Article
John, C., Guyatt, A. L., Shrine, N., Packer, R., Olafsdottir, T. A., Liu, J., …Tobin, M. D. (2022). Genetic Associations and Architecture of Asthma-COPD Overlap. Chest, 161(5), 1155-1166. https://doi.org/10.1016/j.chest.2021.12.674

Background Some people have characteristics of both asthma and COPD (asthma-COPD overlap), and evidence suggests they experience worse outcomes than those with either condition alone. Research Question What is the genetic architecture of asthma-CO... Read More about Genetic Associations and Architecture of Asthma-COPD Overlap.