All Outputs (2)

Neuroprotection Against NMDA-Induced Retinal Damage by Philanthotoxin-343 Involves Reduced Nitrosative Stress (2021)
Journal Article
Mohamad, M. H. N., Abu, I. F., Fazel, M. F., Agarwal, R., Iezhitsa, I., Juliana, N., …Franzyk, H. (2021). Neuroprotection Against NMDA-Induced Retinal Damage by Philanthotoxin-343 Involves Reduced Nitrosative Stress. Frontiers in Pharmacology, 12, Article 798794. https://doi.org/10.3389/fphar.2021.798794

N-methyl-D-aspartate receptor (NMDAR) overstimulation is known to mediate neurodegeneration, and hence represents a relevant therapeutic target for neurodegenerative disorders including glaucoma. This study examined the neuroprotective effects of phi... Read More about Neuroprotection Against NMDA-Induced Retinal Damage by Philanthotoxin-343 Involves Reduced Nitrosative Stress.

The Effects of Structural Alterations in the Polyamine and Amino Acid Moieties of Philanthotoxins on Nicotinic Acetylcholine Receptor Inhibition in the Locust, Schistocerca gregaria (2021)
Journal Article
Luck, V. L., Richards, D. P., Shaikh, A. Y., Franzyk, H., & Mellor, I. R. (2021). The Effects of Structural Alterations in the Polyamine and Amino Acid Moieties of Philanthotoxins on Nicotinic Acetylcholine Receptor Inhibition in the Locust, Schistocerca gregaria. Molecules, 26(22), Article 7007. https://doi.org/10.3390/molecules26227007

Alterations in the polyamine and amino acid (tyrosine) moieties of philanthotoxin‐343 (PhTX‐343) were investigated for their effects on the antagonism of nicotinic acetylcholine receptors (nAChRs) isolated from the locust (Schistocerca gregaria) mush... Read More about The Effects of Structural Alterations in the Polyamine and Amino Acid Moieties of Philanthotoxins on Nicotinic Acetylcholine Receptor Inhibition in the Locust, Schistocerca gregaria.