All Outputs (35)

The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin ?? (2014)
Journal Article

Lemur tyrosine kinase 3 (LMTK3) is associated with cell proliferation and endocrine resistance in breast cancer. We found that, in cultured breast cancer cell lines, LMTK3 promotes the development of a metastatic phenotype by inducing the expression... Read More about The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin ??.

KSR1 regulates BRCA1 degradation and inhibits breast cancer growth (2014)
Journal Article
Stebbing, J., Zhang, H., Xu, Y., Lit, L. C., Green, A., Grothey, A., …Giamas, G. (2015). KSR1 regulates BRCA1 degradation and inhibits breast cancer growth. Oncogene, 34(16), 2103-2114. https://doi.org/10.1038/onc.2014.129

Kinase suppressor of Ras-1 (KSR1) facilitates signal transduction in Ras-dependent cancers, including pancreatic and lung carcinomas but its role in breast cancer has not been well studied. Here, we demonstrate for the first time it functions as a tu... Read More about KSR1 regulates BRCA1 degradation and inhibits breast cancer growth.

Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients (2014)
Journal Article

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer (2014)
Journal Article
Abdel-Fatah, T. M., Russell, R., Albarakati, N., Maloney, D. J., Dorjsuren, D., Rueda, O. M., …Madhusudan, S. (2014). Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer. Molecular Oncology, 8(7), 1326-1338. https://doi.org/10.1016/j.molonc.2014.04.009

FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of telomere stability and apoptosis. FEN1 may be dysregulated in breast and ovarian cancers and ha... Read More about Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.

HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer (2014)
Journal Article
Abdel-Fatah, T., McArdle, S., Johnson, C., Moseley, P., Ball, G., Pockley, A., …Chan, S. (2014). HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer. British Journal of Cancer, 110(10), 2450-2461. https://doi.org/10.1038/bjc.2014.168

Background: HAGE protein is a known immunogenic cancer-specific antigen. Methods: The biological, prognostic and predictive values of HAGE expression was studied using immunohistochemistry in three cohorts of patients with BC (n ¼ 2147): early prima... Read More about HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer.

Prognostic and biological significance of proliferation and HER2 expression in the luminal class of breast cancer (2014)
Journal Article
Jerjees, D. A., Alabdullah, M., Green, A. R., Alshareeda, A., Macmillan, R. D., Ellis, I. O., & Rakha, E. A. (2014). Prognostic and biological significance of proliferation and HER2 expression in the luminal class of breast cancer. Breast Cancer Research and Treatment, 145(2), 317-330. https://doi.org/10.1007/s10549-014-2941-7

The definition of Luminal-B subclass of breast cancer (BC) varies in literature. In this study, we have compared the proliferation status; assessed using KI67 labeling index (KI67-LI), and HER2-expression in estrogen receptor positive (ER+) BC to ass... Read More about Prognostic and biological significance of proliferation and HER2 expression in the luminal class of breast cancer.

The effect of delay in fixation on HER2 expression in invasive carcinoma of the breast assessed with immunohistochemistry and in situ hybridisation (2014)
Journal Article
Lee, A. H., Key, H. P., Bell, J. A., Kumah, P., Hodi, Z., & Ellis, I. O. (2014). The effect of delay in fixation on HER2 expression in invasive carcinoma of the breast assessed with immunohistochemistry and in situ hybridisation. Journal of Clinical Pathology, 67(7), 573-575. https://doi.org/10.1136/jclinpath-2013-201978

Human epidermal growth receptor-2 overexpressing early operable primary breast cancers in older (>=70 years) women: biology and clinical outcome in comparison with younger (less than 70 years) patients (2014)
Journal Article

Introduction: There is dearth of literature reporting the prevalence and biological characteristics as well as the long-term clinical outcome of human epidermal growth factor receptor-2 (HER2) overexpressing tumours in older women. Currently, resea... Read More about Human epidermal growth receptor-2 overexpressing early operable primary breast cancers in older (>=70 years) women: biology and clinical outcome in comparison with younger (less than 70 years) patients.

Immunoglobulin free light chains are biomarkers of poor prognosis in basal-like breast cancer and are potential targets in tumor-associated inflammation (2014)
Journal Article
Kormelink, T. G., Powe, D. G., Kuijpers, S. A., Abudukelimu, A., Fens, M. H., Pieters, E. H., …Schiffelers, R. M. (2014). Immunoglobulin free light chains are biomarkers of poor prognosis in basal-like breast cancer and are potential targets in tumor-associated inflammation. Oncotarget, 5(10), 3159-3167. https://doi.org/10.18632/oncotarget.1868

Inflammation is an important component of various cancers and its inflammatory cells and mediators have been shown to have prognostic potential. Tumor-infiltrating mast cells can promote tumor growth and angiogenesis, but the mechanism of mast cell a... Read More about Immunoglobulin free light chains are biomarkers of poor prognosis in basal-like breast cancer and are potential targets in tumor-associated inflammation.

Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials (2014)
Journal Article
EBCTCG (Early Breast Cancer Trialists' Collaborative Group), & Ellis, I. (2014). Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet, 383(9935), 2127-2135. https://doi.org/10.1016/s0140-6736%2814%2960488-8

Assessment of microtubule-associated protein (MAP)-Tau expression as a predictive and prognostic marker in TACT; a trial assessing substitution of sequential docetaxel for FEC as adjuvant chemotherapy for early breast cancer (2014)
Journal Article
Irshad, S., Gillett, C., Pinder, S. E., A’Hern, R. P., Dowsett, M., Ellis, I. O., …Ellis, P. (2014). Assessment of microtubule-associated protein (MAP)-Tau expression as a predictive and prognostic marker in TACT; a trial assessing substitution of sequential docetaxel for FEC as adjuvant chemotherapy for early breast cancer. Breast Cancer Research and Treatment, 144(2), 331-341. https://doi.org/10.1007/s10549-014-2855-4

The updated ASCO/CAP guideline recommendations for HER2 testing in the management of invasive breast cancer: a critical review of their implications for routine practice (2014)
Journal Article
Rakha, E. A., Starczynski, J., Lee, A. H. S., & Ellis, I. O. (2014). The updated ASCO/CAP guideline recommendations for HER2 testing in the management of invasive breast cancer: a critical review of their implications for routine practice. Histopathology, 64(5), 609-615. https://doi.org/10.1111/his.12357

DNA polymerase β deficiency is linked to aggressive breast cancer: A comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts (2014)
Journal Article
Abdel-Fatah, T. M., Russell, R., Agarwal, D., Moseley, P., Abayomi, M. A., Perry, C., …Madhusudan, S. (2014). DNA polymerase β deficiency is linked to aggressive breast cancer: A comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts. Molecular Oncology, 8(3), 520-532. https://doi.org/10.1016/j.molonc.2014.01.001

DACH1: Its Role as a Classifier of Long Term Good Prognosis in Luminal Breast Cancer (2014)
Journal Article
Powe, D. G., Dhondalay, G. K. R., Lemetre, C., Allen, T., Habashy, H. O., Ellis, I. O., …Ball, G. R. (2014). DACH1: Its Role as a Classifier of Long Term Good Prognosis in Luminal Breast Cancer. PLoS ONE, 9(1), e84428. https://doi.org/10.1371/journal.pone.0084428

Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer (2014)
Journal Article
Abdel-Fatah, T. M. A., Perry, C., Moseley, P., Johnson, K., Arora, A., Chan, S., …Madhusudan, S. (2014). Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer. Breast Cancer Research and Treatment, 143(3), 411-421. https://doi.org/10.1007/s10549-013-2820-7

Oestrogen metabolites can induce oxidative DNA base damage and generate potentially mutagenic apurinic sites (AP sites) in the genomic DNA. If unrepaired, mutagenic AP sites could drive breast cancer pathogenesis and aggressive phenotypes. Human apur... Read More about Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer.