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Low temperature exposure induces browning of bone marrow stem cell derived adipocytes in vitro (2018)
Journal Article
Velickovic, K., Lugo-Leija, H. A., Bloor, I., Law, J., Sacks, H., Symonds, M. E., & Sottile, V. (2018). Low temperature exposure induces browning of bone marrow stem cell derived adipocytes in vitro. Scientific Reports, 8, doi:10.1038/s41598-018-23267-9. ISSN 2045-2322

Brown and beige adipocytes are characterised as expressing the unique mitochondrial uncoupling protein (UCP)1 for which the primary stimulus in vivo is cold exposure. The extent to which cold-induced UCP1 activation can also be achieved in vitro, and... Read More

The placenta, maternal diet and adipose tissue development in the newborn (2017)
Journal Article
Symonds, M. E., Bloor, I., Ojha, S., & Budge, H. (2017). The placenta, maternal diet and adipose tissue development in the newborn. Annals of Nutrition and Metabolism, 70(3), doi:10.1159/000464301. ISSN 0250-6807

Background: A majority of adipose tissue present in the newborn possess the unique mitochondrial protein, uncoupling protein (UCP1). It is thus highly metabolically active and capable of producing 300 times more heat per unit mass than any other orga... Read More

Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep (2013)
Journal Article
Bloor, I. D., Sébert, S. P., Saroha, V., Gardner, D. S., Keisler, D. H., Budge, H., …Mahajan, R. P. (2013). Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep. Endocrinology, 154(10), doi:10.1210/en.2013-1207. ISSN 0013-7227

Sex is a major factor determining adipose tissue distribution and the subsequent adverse effects of obesity-related disease including type 2 diabetes. The role of gender on juvenile obesity and the accompanying metabolic and inflammatory responses is... Read More