Genome-wide association scan of neuropathic pain symptoms post total joint replacement highlights a variant in the protein-kinase C gene

Warner, Sophie C.; van Meurs, Joyce B.J.; Schiphof, Dieuwke; Bierma-Zeinstra, Sita M.; Hofman, Albert; Uitterlinden, Andre G.; Richardson, Helen; Jenkins, Wendy; Doherty, Michael; Valdes, Ana M.

doi:10.1038/ejhg.2016.196

All Outputs (5)

Association between serum urate and flares in people with gout and evidence for surrogate status: a secondary analysis of two randomised controlled trials (2021)
Journal Article

Background Use of serum urate as a treatment target and outcome measure has become controversial in view of the 2017 American College of Physicians guidelines, which advocated a treat-to-symptom rather than a treat-to-target serum urate approach to... Read More about Association between serum urate and flares in people with gout and evidence for surrogate status: a secondary analysis of two randomised controlled trials.

Efficacy and cost-effectiveness of nurse-lead care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial (2018)
Journal Article

Background: In the UK gout management is suboptimal, only 40% of patients receiving urate-lowering therapy (ULT), usually without titration to a target serum urate (SU) level. Nurses successfully manage many diseases in primary care. This trial compa... Read More about Efficacy and cost-effectiveness of nurse-lead care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial.

Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study (2018)
Journal Article

Aim To explore risk factors that may influence knee pain (KP) through central or peripheral mechanisms. Methods A questionnaire-based prospective community cohort study with KP defined as pain in or around a knee on most days for at least a... Read More about Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study.

Knee pain and related health in the community study (KPIC): a cohort study protocol (2017)
Journal Article

Background: The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence and progression and to identify possible phenotypes and their a... Read More about Knee pain and related health in the community study (KPIC): a cohort study protocol.

Genome-wide association scan of neuropathic pain symptoms post total joint replacement highlights a variant in the protein-kinase C gene (2017)
Journal Article

Neuropathic pain-like joint symptoms (NP) are seen in a proportion of individuals diagnosed with osteoarthritis (OA) and post total joint replacement (TJR). In this study, we performed a genome-wide association study (GWAS) using NP as defined by the... Read More about Genome-wide association scan of neuropathic pain symptoms post total joint replacement highlights a variant in the protein-kinase C gene.