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All Outputs (21)

Impact of tissue factor expression and administration routes on thrombosis development induced by mesenchymal stem/stromal cell infusions: re-evaluating the dogma (2024)
Journal Article
Hoang, V. T., Le, D. S., Hoang, D. M., Phan, T. T. K., Ngo, L. A. T., Nguyen, T. K., Bui, V. A., & Nguyen Thanh, L. (2024). Impact of tissue factor expression and administration routes on thrombosis development induced by mesenchymal stem/stromal cell infusions: re-evaluating the dogma. Stem Cell Research and Therapy, 15(1), Article 56. https://doi.org/10.1186/s13287-023-03582-3

Background: Hyperactive coagulation might cause dangerous complications such as portal vein thrombosis and pulmonary embolism after mesenchymal stem/stromal cell (MSC) therapy. Tissue factor (TF), an initiator of the extrinsic coagulation pathway, ha... Read More about Impact of tissue factor expression and administration routes on thrombosis development induced by mesenchymal stem/stromal cell infusions: re-evaluating the dogma.

Outcomes of autologous bone marrow mononuclear cell administration in the treatment of neurologic sequelae in children with spina bifida (2023)
Journal Article
Nguyen, L. T., Le, H. T., Nguyen, K. T., Bui, H. T., Nguyen, A. P. T., Ngo, D. V., Hoang, D. M., & Ngo, M. D. (2023). Outcomes of autologous bone marrow mononuclear cell administration in the treatment of neurologic sequelae in children with spina bifida. Stem Cell Research and Therapy, 14(1), 1-11. https://doi.org/10.1186/s13287-023-03349-w

Background:

To evaluate the safety and efficacy of autologous bone marrow mononuclear cell (BMMNC) infusion in the management of neurological sequelae in children with spina bifida (SB).

Methods:

BMMNCs were harvested from bilateral anter... Read More about Outcomes of autologous bone marrow mononuclear cell administration in the treatment of neurologic sequelae in children with spina bifida.

Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns (2023)
Journal Article
Nguyen, Q. T., Thanh, L. N., Hoang, V. T., Phan, T. T., Heke, M., & Hoang, D. M. (2023). Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns. Cellular and Molecular Neurobiology, 43(7), 3211-3250. https://doi.org/10.1007/s10571-023-01377-x

Abstract: Bone marrow-derived mononuclear cells (BMMNCs) have been used for decades in preclinical and clinical studies to treat various neurological diseases. However, there is still a knowledge gap in the understanding of the underlying mechanisms... Read More about Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns.

Advanced cell-based products generated via automated and manual manufacturing platforms under the quality by design principle: Are they equivalent or different? (2023)
Journal Article
Hoang, D. M., Nguyen, Q. T., Phan, T. T., Ngo, A. T., Pham, P. T., Bach, T. Q., Le, P. T., Bui, H. T., & Thanh, L. N. (2023). Advanced cell-based products generated via automated and manual manufacturing platforms under the quality by design principle: Are they equivalent or different?. Heliyon, 9(5), Article e15946. https://doi.org/10.1016/j.heliyon.2023.e15946

Mesenchymal stem/stromal cells (MSCs) are multipotent stem cells that can be isolated from bone marrow, adipose tissue, the umbilical cord, dental pulp, etc. These cells have unique properties that give them excellent therapeutic potential, including... Read More about Advanced cell-based products generated via automated and manual manufacturing platforms under the quality by design principle: Are they equivalent or different?.

“Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction: Literature reviews and study design of a clinical trial” (2022)
Journal Article
Hoang, V. T., Nguyen, H. P., Nguyen, V. N., Hoang, D. M., Nguyen, T. S. T., & Nguyen Thanh, L. (2022). “Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction: Literature reviews and study design of a clinical trial”. Frontiers in Cell and Developmental Biology, 10, 1-18. https://doi.org/10.3389/fcell.2022.956274

Hormone imbalance and female sexual dysfunction immensely affect perimenopausal female health and quality of life. Hormone therapy can improve female hormone deficiency, but long-term use increases the risk of cardiovascular diseases and cancer. Ther... Read More about “Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction: Literature reviews and study design of a clinical trial”.

Stem cell-based therapy for human diseases (2022)
Journal Article
M. Hoang, D. M., Pham, P. T., Bach, T. Q., Ngo, A. T., Nguyen, Q. T., Phan, T. T., Nguyen, G. H., Le, P. T., Hoang, V. T., Forsyth, N. R., Heke, M., & Nguyen, L. T. (2022). Stem cell-based therapy for human diseases. Signal Transduction and Targeted Therapy, 7(1), Article 272. https://doi.org/10.1038/s41392-022-01134-4

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells... Read More about Stem cell-based therapy for human diseases.

Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti-N-Methyl-d-Aspartate Receptor Encephalitis: First Case Report (2022)
Journal Article
Nguyen Thanh, L., Hoang, V. T., Le Thu, H., Nguyen, P. A. T., Hoang, D. M., Ngo, D. V., Cao Vu, H., Nguyen Thi Bich, V., & Heke, M. (2022). Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti-N-Methyl-d-Aspartate Receptor Encephalitis: First Case Report. Cell Transplantation, 31, https://doi.org/10.1177/09636897221110876

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is caused by altered patient immune reactions. This study reports the first patient with severe neurologic sequelae after NMDA receptor encephalitis treated with allogeneic umbilical cord–derived... Read More about Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti-N-Methyl-d-Aspartate Receptor Encephalitis: First Case Report.

Autologous bone marrow mononuclear cell infusion for liver cirrhosis after the Kasai operation in children with biliary atresia (2022)
Journal Article
Nguyen, T. L., Nguyen, H. P., Ngo, D. M., Ha, T. H. T., Mai, K. A., Bui, T. H., Nguyen, P. V., Pham, L. H., Hoang, D. M., & Cao, A. D. T. (2022). Autologous bone marrow mononuclear cell infusion for liver cirrhosis after the Kasai operation in children with biliary atresia. Stem Cell Research and Therapy, 13(1), 1-11. https://doi.org/10.1186/s13287-022-02762-x

Aim: To evaluate the safety and early outcomes of autologous bone marrow mononuclear cell (BMMNC) infusion for liver cirrhosis due to biliary atresia (BA) after Kasai operation.

Methods: An open-label clinical trial was performed from January 201... Read More about Autologous bone marrow mononuclear cell infusion for liver cirrhosis after the Kasai operation in children with biliary atresia.

Human Adipose-Derived Mesenchymal Stromal Cells Exhibit High HLA-DR Levels and Altered Cellular Characteristics under a Xeno-free and Serum-free Condition (2021)
Journal Article
Dam, P. T., Hoang, V. T., Bui, H. T. H., Hang, L. M., Hoang, D. M., Nguyen, H. P., Lien, H. T., Tran, H. T. T., Nguyen, X. H., & Nguyen Thanh, L. (2021). Human Adipose-Derived Mesenchymal Stromal Cells Exhibit High HLA-DR Levels and Altered Cellular Characteristics under a Xeno-free and Serum-free Condition. Stem Cell Reviews and Reports, 17(6), 2291-2303. https://doi.org/10.1007/s12015-021-10242-7

Background: We have observed an increased expression of negative markers in some clinical-grade, xeno- and serum-free cultured adipose-derived mesenchymal stem/stromal cell (ADMSC) samples. It gave rise to concern that xeno- and serum-free conditions... Read More about Human Adipose-Derived Mesenchymal Stromal Cells Exhibit High HLA-DR Levels and Altered Cellular Characteristics under a Xeno-free and Serum-free Condition.

Clinically relevant preservation conditions for mesenchymal stem/stromal cells derived from perinatal and adult tissue sources (2021)
Journal Article
Ngo, A. T., Le, H. M., Trinh, N. T., Jun, A. P. G., Bach, T. Q., Bui, H. T., Hoang, V. T., Bui, A. V., Nguyen, L. T., & Hoang, D. M. (2021). Clinically relevant preservation conditions for mesenchymal stem/stromal cells derived from perinatal and adult tissue sources. Journal of Cellular and Molecular Medicine, 25(22), 10747-10760. https://doi.org/10.1111/jcmm.17016

The interplay between mesenchymal stem/stromal cells (MSCs) and preservation conditions is critical to maintain the viability and functionality of these cells before administration. We observed that Ringer lactate (RL) maintained high viability of bo... Read More about Clinically relevant preservation conditions for mesenchymal stem/stromal cells derived from perinatal and adult tissue sources.

Clinical Study of Mesenchymal Stem/Stromal Cell Therapy for the Treatment of Frailty: A Proposed Experimental Design for Therapeutic and Mechanistic Investigation (2021)
Journal Article
Hoang, D. M., Nguyen, K. T., Hoang, V. T., Dao, L. T., Bui, H. T., Ho, T. T., Nguyen, T. T., Ngo, A. T., Nguyen, H. K., & Thanh, L. N. (2022). Clinical Study of Mesenchymal Stem/Stromal Cell Therapy for the Treatment of Frailty: A Proposed Experimental Design for Therapeutic and Mechanistic Investigation. Journals of Gerontology, Series A, 77(7), 1287-1291. https://doi.org/10.1093/gerona/glab326

Frailty, a specific condition of increased vulnerability and reduced general health associated with aging in older people, is an emerging problem worldwide with major implications for clinical practice and public health. Recent preclinical and clinic... Read More about Clinical Study of Mesenchymal Stem/Stromal Cell Therapy for the Treatment of Frailty: A Proposed Experimental Design for Therapeutic and Mechanistic Investigation.

Type 2 Diabetes Mellitus Duration and Obesity alter the Efficacy of Autologously Transplanted Bone Marrow-derived Mesenchymal Stem/Stromal Cells (2021)
Journal Article
Nguyen, L. T., Hoang, D. M., Nguyen, K. T., Bui, D. M., Nguyen, H. T., Le, H. T., Hoang, V. T., Bui, H. T., Dam, P. T., Hoang, X. T., Ngo, A. T., Le, H. M., Phung, N. Y., Vu, D. M., Duong, T. T., Nguyen, T. D., Ha, L. T., Bui, H. T., Nguyen, H. K., Heke, M., & Bui, A. V. (2021). Type 2 Diabetes Mellitus Duration and Obesity alter the Efficacy of Autologously Transplanted Bone Marrow-derived Mesenchymal Stem/Stromal Cells. Stem Cells Translational Medicine, 10(9), 1266-1278. https://doi.org/10.1002/sctm.20-0506

Human bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) represent promising stem cell therapy for the treatment of type 2 diabetes mellitus (T2DM), but the results of autologous BM-MSC administration in T2DM patients are contradictory. The... Read More about Type 2 Diabetes Mellitus Duration and Obesity alter the Efficacy of Autologously Transplanted Bone Marrow-derived Mesenchymal Stem/Stromal Cells.

Comparative Bioactivity Analysis for Off-the-Shelf and Culture–Rescued Umbilical Cord-Derived Mesenchymal Stem/Stromal Cells in a Xeno- and Serum-Free Culture System (2021)
Journal Article
Nguyen, M. Q., Bui, H. T., Tuyet, A. N. T., Nhung, T. T. H., Hoang, D. M., Liem, N. T., & Hoang, V. T. (2021). Comparative Bioactivity Analysis for Off-the-Shelf and Culture–Rescued Umbilical Cord-Derived Mesenchymal Stem/Stromal Cells in a Xeno- and Serum-Free Culture System. Cell Transplantation, Article 30. https://doi.org/10.1177/09636897211039441

We recently reported a standardized xeno- and serum-free culture platform to isolate and expand umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs). Comparing populations from the same passage, cells that were cryopreserved and culture-re... Read More about Comparative Bioactivity Analysis for Off-the-Shelf and Culture–Rescued Umbilical Cord-Derived Mesenchymal Stem/Stromal Cells in a Xeno- and Serum-Free Culture System.

Can Autologous Adipose-Derived Mesenchymal Stem Cell Transplantation Improve Sexual Function in People with Sexual Functional Deficiency? (2021)
Journal Article
Nguyen Thanh, L., Dam, P. T., Nguyen, H. P., Nguyen, T. S. T., To, H. M., Nguyen, H. B., Luu, N. A., & Hoang, D. M. (2021). Can Autologous Adipose-Derived Mesenchymal Stem Cell Transplantation Improve Sexual Function in People with Sexual Functional Deficiency?. Stem Cell Reviews and Reports, 17(6), 2153-2163. https://doi.org/10.1007/s12015-021-10196-w

Background: Sexual functional deficiency occurs at some point in life and becomes a problematic issue in middle-aged adulthood. Regenerative medicine, especially mesenchymal stem cell (MSC) transplantation, has developed extensively, with preclinical... Read More about Can Autologous Adipose-Derived Mesenchymal Stem Cell Transplantation Improve Sexual Function in People with Sexual Functional Deficiency?.

Allogeneic human umbilical cord-derived mesenchymal stem/stromal cells for chronic obstructive pulmonary disease (COPD): study protocol for a matched case–control, phase I/II trial (2021)
Journal Article
Hoang, D. M., Nguyen, K. T., Nguyen, A. H., Nguyen, B. N., & Nguyen, L. T. (2021). Allogeneic human umbilical cord-derived mesenchymal stem/stromal cells for chronic obstructive pulmonary disease (COPD): study protocol for a matched case–control, phase I/II trial. BMJ Open, 11(5), Article e045788. https://doi.org/10.1136/bmjopen-2020-045788

Introduction The global prevalence of chronic obstructive pulmonary disease (COPD) is increasing, and it has become a major public health burden worldwide, including in Vietnam. A large body of preclinical and clinical studies supports the safety of... Read More about Allogeneic human umbilical cord-derived mesenchymal stem/stromal cells for chronic obstructive pulmonary disease (COPD): study protocol for a matched case–control, phase I/II trial.

Standardized xeno- and serum-free culture platform enables large-scale expansion of high-quality mesenchymal stem/stromal cells from perinatal and adult tissue sources (2020)
Journal Article
Hoang, V. T., Trinh, Q. M., Phuong, D. T. M., Bui, H. T. H., Hang, L. M., Ngan, N. T. H., Anh, N. T. T., Nhi, P. Y., Nhung, T. T. H., Lien, H. T., Nguyen, T. D., Thanh, L. N., & Hoang, D. M. (2021). Standardized xeno- and serum-free culture platform enables large-scale expansion of high-quality mesenchymal stem/stromal cells from perinatal and adult tissue sources. Cytotherapy, 23(1), 88-99. https://doi.org/10.1016/j.jcyt.2020.09.004

Background aims
Mesenchymal stem/stromal cells (MSCs) are of interest for the treatment of graft-versus-host disease, autoimmune diseases, osteoarthritis and neurological and cardiovascular diseases. Increasing numbers of clinical trials emphasize t... Read More about Standardized xeno- and serum-free culture platform enables large-scale expansion of high-quality mesenchymal stem/stromal cells from perinatal and adult tissue sources.

Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants (2020)
Journal Article
Nguyen, L. T., Trieu, T. T., Bui, H. T., Hoang, V. T., Nguyen, A. T., Trinh, N. T., Nguyen, K. T., & Hoang, D. M. (2020). Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants. Journal of Translational Medicine, 18, Article 398. https://doi.org/10.1186/s12967-020-02568-6

Background: Bronchopulmonary dysplasia (BPD) is a severe condition in premature infants that compromises lung function and necessitates oxygen support. Despite major improvements in perinatal care minimizing the devastating effects, BPD remains the m... Read More about Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants.

Allogeneic Administration of Human Umbilical Cord-derived Mesenchymal Stem/Stromal Cells for Bronchopulmonary Dysplasia: Preliminary Outcomes in Four Vietnamese Infants (2020)
Preprint / Working Paper
Thanh, L. N., Trieu, T. T. H., Bui, H. T. .., Hoang, V. T., Nguyen, A. T. T., Trinh, N. T. H., Nguyen, K. T., & Hoang, D. M. Allogeneic Administration of Human Umbilical Cord-derived Mesenchymal Stem/Stromal Cells for Bronchopulmonary Dysplasia: Preliminary Outcomes in Four Vietnamese Infants

Background: Bronchopulmonary dysplasia (BPD) is a severe condition in premature infants that compromises lung function and necessitates oxygen support. Despite major improvements in perinatal care minimizing the devastating effects, BPD remains the m... Read More about Allogeneic Administration of Human Umbilical Cord-derived Mesenchymal Stem/Stromal Cells for Bronchopulmonary Dysplasia: Preliminary Outcomes in Four Vietnamese Infants.