All Outputs (170)
Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non-alcoholic fatty liver disease (2018)
Journal Article
Background & Aims Chronic liver disease presents a major global public health challenge. Stratification of asymptomatic, at-risk patients in primary care using non-invasive methods has the potential to address this by identifying those likely to pr... Read More about Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non-alcoholic fatty liver disease.
Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease (2018)
Journal Article
Purpose: This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral... Read More about Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease.
A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis (2018)
Journal Article
The aim of this study was to evaluate cenicriviroc (CVC), a dual antagonist of C-C chemokine receptor types 2 and 5, for treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis. A randomized, double-blind, multinational phase 2b study e... Read More about A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis.
Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography (2017)
Journal Article
Background: Rising cirrhosis incidence and mortality in the United Kingdom has been attributed predominantly to excess alcohol consumption. However, metabolic risk factors such as type 2 diabetes and obesity may also be important. Aim: To screen at-... Read More about Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography.
Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans (2017)
Journal Article
Cereal grain based porridges are commonly consumed throughout the world. Whilst some data are available for varieties that are popular in the Western world such as oats and rye, other ‘ancient’ grains used in the East and in Africa such as millets ar... Read More about Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans.
Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma (2017)
Journal Article
Background: A meta-analysis comparing drug-eluting beads transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (cTACE) has recently been published. On balance, no significant differences were found in terms of o... Read More about Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma.
Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis (2017)
Journal Article
Laboratory tests can play an important role in assessment of alcoholic patients, including for evaluation of liver damage and as markers of alcohol intake. Evidence on test performance should lead to better selection of appropriate tests and improved... Read More about Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis.
Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites (2017)
Journal Article
A 43-year-old man had a peritoneovenous shunt inserted for the treatment of chylous ascites secondary to myelofibrosis. Despite being on anticoagulation for superior mesenteric vein thrombosis, he developed shunt dysfunction within two weeks of inser... Read More about Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites.
Minocycline hepatotoxicity: clinical characterization and identification of HLA-B? 35:02 as a risk factor (2017)
Journal Article
Minocycline hepatotoxicity can present with prominent autoimmune features in previously healthy individuals. The aim of this study was to identify genetic determinants of minocycline DILI in a well-phenotyped cohort of patients. Methods: Caucasian pa... Read More about Minocycline hepatotoxicity: clinical characterization and identification of HLA-B? 35:02 as a risk factor.
Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study (2017)
Journal Article
Background: Among patients with cirrhosis, only those determined to be at risk for hepatocellular carcinoma (HCC) should undergo surveillance. However, little is known about how different aetiologies of cirrhosis affect risk for HCC. Aim: To quantif... Read More about Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study.
Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review (2017)
Journal Article
As of 2016, there is no evidence-based pathway to stratify the risk of chronic liver disease in a general population setting. Non-invasive tests of liver fibrosis might provide a mechanism for earlier diagnosis. These tests have been extensively vali... Read More about Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study (2016)
Journal Article
Background & aims: We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. Methods: We performed a GWAS of 862 pe... Read More about Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study.
Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: a randomized crossover study (2016)
Journal Article
Aim: To investigate the acute and longer-term effects of low (LGI) versus high glycaemic index (HGI) diets on hepatic fat and glycogen accumulation and related blood measures in healthy volunteers. Methods: Eight healthy men (age 20.1 � 0.4 years,... Read More about Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: a randomized crossover study.
Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging (2016)
Journal Article
Background & Aims Hepatic venous pressure gradient (HVPG) measurement is currently the only validated technique to accurately evaluate changes in portal pressure. In this study, we evaluate the use of non-contrast quantitative magnetic resonance i... Read More about Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging.
Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography (2016)
Journal Article
© 2016 The Author(s). This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after endoscopic biliary drainage. Dendritic cell (DC) subsets and t... Read More about Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography.
The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope: a prospective diagnostic pilot study (2016)
Journal Article
Background & Aims Screening for oesophageal varices (OV) using conventional oesophagogastroduodenoscopy (C-OGD) is invasive and requires costly monitoring, recovery, and decontamination facilities. We aimed to evaluate the technical feasibility, acc... Read More about The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope: a prospective diagnostic pilot study.
Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms? (2016)
Journal Article
Multiple genetic and environmental factors interact to determine an individual?s predisposition to non-alcoholic fatty liver disease and its phenotypic characteristics. Association studies have found a number of alleles associated with the developmen... Read More about Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms?.
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study (2015)
Journal Article
Background Glucagon-like peptide-1 (GLP-1) analogues reduce hepatic steatosis, concentrations of liver enzymes, and insulin resistance in murine models of fatty liver disease. These analogues are licensed for type 2 diabetes, but their efficacy in... Read More about Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study.