All Outputs (9)

Unacceptable failures: the final report of the Lancet Commission into liver disease in the UK (2019)
Journal Article
Rice, P., Williams, R., Newsome, P., Aithal, G., Morling, J., Alexander, G. J., …Yeoman, A. (2020). Unacceptable failures: the final report of the Lancet Commission into liver disease in the UK. Lancet, 395(10219), 226-239. https://doi.org/10.1016/S0140-6736%2819%2932908-3

This final report of the Lancet Commission into liver disease in the UK stresses the continuing increase in burden of liver disease from excess alcohol consumption and obesity, with high levels of hospital admissions which are worsening in deprived a... Read More about Unacceptable failures: the final report of the Lancet Commission into liver disease in the UK.

Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis (2019)
Journal Article
Astbury, S., Atallah, E., Vijay, A., Aithal, G., Grove, J., & Valdes, A. (2020). Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis. Gut Microbes, 11(3), 569-580. https://doi.org/10.1080/19490976.2019.1681861

There is increasing evidence for the role of gut microbial composition in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Non-alcoholic steatohepatitis (NASH) is the most serious form of NAFLD where inflammation causes liver damage tha... Read More about Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis.

Transient elastography for screening of liver fibrosis: cost-effectiveness analysis from six prospective cohorts in Europe and Asia (2019)
Journal Article
Serra-Burriel, M., Graupera, I., Torán, P., Thiele, M., Roulot, D., Wai-Sun Wong, V., …Lammert, F. (2019). Transient elastography for screening of liver fibrosis: cost-effectiveness analysis from six prospective cohorts in Europe and Asia. Journal of Hepatology, 71(6), 1141-1151. https://doi.org/10.1016/j.jhep.2019.08.019

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) pose an important challenge to current clinical healthcare pathways due to a large number of at-risk patients. Therefore, we aimed to explore the cost-effec... Read More about Transient elastography for screening of liver fibrosis: cost-effectiveness analysis from six prospective cohorts in Europe and Asia.

Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug‐Induced Liver Injury (2019)
Journal Article
for the US DILIN Investigators, Bonkovsky, H. L., Severson, T., Nicoletti, P., Barnhart, H., Serrano, J., …Odin, J. (2019). Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug‐Induced Liver Injury. Hepatology Communications, 3(8), 1032-1035. https://doi.org/10.1002/hep4.1382

With the application of genetic testing to contemporary medical diagnostics and practice, it has become apparent that the phenotypes of many disorders are modulated by host genetic factors. The aim of the current study was to determine whether select... Read More about Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug‐Induced Liver Injury.

Natural History of Histologically-proven Alcohol Related Liver Disease: A systematic review (2019)
Journal Article
Parker, R., Aithal, G. P., Becker, U., Gleeson, D., Masson, S., Wyatt, J. I., & Rowe, I. A. (2019). Natural History of Histologically-proven Alcohol Related Liver Disease: A systematic review. Journal of Hepatology, 71(3), 586-593. https://doi.org/10.1016/j.jhep.2019.05.020

Background: Studies into the natural history of alcohol related liver disease (ArLD) to date have lacked long-term follow-up, large numbers of participants, or both. We performed a systematic review to summarise studies that describe the natural hi... Read More about Natural History of Histologically-proven Alcohol Related Liver Disease: A systematic review.

Of Potions, Poisons, Polygonum and Pre‐emptive Polymorphism (2019)
Journal Article
Aithal, G. P. (2019). Of Potions, Poisons, Polygonum and Pre‐emptive Polymorphism. Hepatology, 70(1), 8-10. https://doi.org/10.1002/hep.30798

There are scores of references to plants and herbs in William Shakespeare's plays; he was obviously very knowledgeable about their perceived effects. The secret to the highly potent love potion Oberon asks Puck to find, lies in the purple, yellow and... Read More about Of Potions, Poisons, Polygonum and Pre‐emptive Polymorphism.

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China (2019)
Journal Article
Shen, T., Liu, Y., Shang, J., Xie, Q., Li, J., Yan, M., …Chen, C. (2019). Incidence and Etiology of Drug-Induced Liver Injury in Mainland China. Gastroenterology, 156(8), 2230-2241.e11. https://doi.org/10.1053/j.gastro.2019.02.002

Background & Aims: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China. Methods: We collected data on a total of 25,927 confirmed DILI cases, hospitalized from... Read More about Incidence and Etiology of Drug-Induced Liver Injury in Mainland China.

Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles (2019)
Journal Article
Nicoletti, P., Aithal, G. P., Chamberlain, T. C., Coulthard, S., Alshabeeb, M., Grove, J. I., …Daly, A. K. (2019). Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles. Clinical Pharmacology and Therapeutics, 106(1), 245-253. https://doi.org/10.1002/cpt.1375

© 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics Some patients prescribed flucloxacillin (~0.01%) develop drug-induced liver injury (DILI). HLA-B*57:01 is an established gene... Read More about Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles.

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury (2019)
Journal Article
Cirulli, E. T., Nicoletti, P., Abramson, K., Andrade, R. J., Bjornsson, E. S., Chalasani, N., …Watkins, P. B. (2019). A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury. Gastroenterology,

Background & Aims: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility. Methods: We performed a genome-wide association study of... Read More about A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.