All Outputs (5)

In silico pro-arrhythmia assessment: Can the results of the thorough QT study be predicted? (2014)
Journal Article
Mirams, G., Davies, M., Stott, J., Rodriguez, B., Cui, Y., Noble, D., Gavaghan, D., & Abi-Gerges, N. (2014). In silico pro-arrhythmia assessment: Can the results of the thorough QT study be predicted?. Journal of Pharmacological and Toxicological Methods, 70(3), 318. https://doi.org/10.1016/j.vascn.2014.03.033

In early drug development, high-throughput cardiac ion channel screening data are now available routinely and relatively cheaply. In-silico approaches that use these data have been proposed to predict the results of: later safety tests; human clinica... Read More about In silico pro-arrhythmia assessment: Can the results of the thorough QT study be predicted?.

Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue (2014)
Journal Article
Walmsley, J., Mirams, G. R., Pitt-Francis, J., Rodriguez, B., & Burrage, K. (2015). Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue. Journal of Theoretical Biology, 365, 325-336. https://doi.org/10.1016/j.jtbi.2014.10.029

Prediction of Thorough QT study results using action potential simulations based on ion channel screens (2014)
Journal Article

Ten Simple Rules for Effective Computational Research (2014)
Journal Article
Osborne, J. M., Bernabeu, M. O., Bruna, M., Calderhead, B., Cooper, J., Dalchau, N., …Deane, C. (2014). Ten Simple Rules for Effective Computational Research. PLoS Computational Biology, 10(3), Article e1003506. https://doi.org/10.1371/journal.pcbi.1003506

Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures (2014)
Presentation / Conference Contribution
A.B. Burton, R., Stephens, G., Sharkey, A., Bilton, S., Larsen, H., Kramer, H., Schmidt, C., Molina, C., Li, D., Mirams, G., Robinson, C., Paterson, D., & Bub, G. (2014, February). Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures. Presented at 58th Annual Meeting Biophysical Society, San Francisco

A variety of arrhythmias have been attributed to formation of large scale patterns of excitation such as formation and break-up of spiral waves. We investigate the relationship between neuronal activity and evolution of macroscopic spatiotemporal dyn... Read More about Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures.