All Outputs (4)

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing (2012)
Journal Article
Mirams, G. R., Davies, M. R., Cui, Y., Kohl, P., & Noble, D. (2012). Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing. British Journal of Pharmacology, 167(5), 932-945. https://doi.org/10.1111/j.1476-5381.2012.02020.x

Concerns over cardiac side effects are the largest single cause of compound attrition during pharmaceutical drug development. For a number of years, biophysically detailed mathematical models of cardiac electrical activity have been used to explore h... Read More about Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.

Evaluation of computational modelling as a preclinical proarrhythmic safety assay (2012)
Presentation / Conference Contribution
Mirams, G., Beattie, K., Cui, Y., Luscombe, C., Williams, G., Gavaghan, D., & McMahon, N. (2012, October). Evaluation of computational modelling as a preclinical proarrhythmic safety assay. Presented at Safety Pharmacology Society Annual Meeting, Phoenix, AZ

Many cardiac ion channels are prone to reduced current flow following blockade by pharmaceutical compounds. High throughput screening technologies now allow us to establish this reduction in activity routinely and relatively cheaply. It would be adva... Read More about Evaluation of computational modelling as a preclinical proarrhythmic safety assay.

A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt (2012)
Journal Article
Mirams, G. R., Fletcher, A. G., Maini, P. K., & Byrne, H. M. (2012). A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt. Journal of Theoretical Biology, 312, 143-156. https://doi.org/10.1016/j.jtbi.2012.08.002

The surface epithelium lining the intestinal tract renews itself rapidly by a coordinated programme of cell proliferation, migration and differentiation events that is initiated in the crypts of Lieberkühn. It is generally believed that colorectal ca... Read More about A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt.

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG (2012)
Journal Article
Jonsson, M. K., Vos, M. A., Mirams, G. R., Duker, G., Sartipy, P., De Boer, T. P., & Van Veen, T. A. (2012). Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. Journal of Molecular and Cellular Cardiology, 52(5), 998-1008. https://doi.org/10.1016/j.yjmcc.2012.02.002

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description of their basic electrophysiology and extensive testing, and mechanistic explanations, of their overal... Read More about Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.