All Outputs (4)

An integrative computational model for intestinal tissue renewal (2009)
Journal Article
Van Leeuwen, I. M., Mirams, G. R., Walter, A., Fletcher, A., Murray, P., Osborne, J., …Byrne, H. M. (2009). An integrative computational model for intestinal tissue renewal. Cell Proliferation, 42(5), 617-636. https://doi.org/10.1111/j.1365-2184.2009.00627.x

Objectives: The luminal surface of the gut is lined with a monolayer of epithelial cells that acts as a nutrient absorptive engine and protective barrier. To maintain its integrity and functionality, the epithelium is renewed every few days. Theoreti... Read More about An integrative computational model for intestinal tissue renewal.

Chaste: A test-driven approach to software development for biological modelling (2009)
Journal Article
Pitt-Francis, J., Pathmanathan, P., Bernabeu, M. O., Bordas, R., Cooper, J., Fletcher, A. G., …Gavaghan, D. J. (2009). Chaste: A test-driven approach to software development for biological modelling. Computer Physics Communications, 180(12), 2452-2471. https://doi.org/10.1016/j.cpc.2009.07.019

Chaste ('Cancer, heart and soft-tissue environment') is a software library and a set of test suites for computational simulations in the domain of biology. Current functionality has arisen from modelling in the fields of cancer, cardiac physiology an... Read More about Chaste: A test-driven approach to software development for biological modelling.

A multiple timescale analysis of a mathematical model of the Wnt/β-catenin signalling pathway (2009)
Journal Article
Mirams, G. R., Byrne, H. M., & King, J. R. (2010). A multiple timescale analysis of a mathematical model of the Wnt/β-catenin signalling pathway. Journal of Mathematical Biology, 60(1), 131-160. https://doi.org/10.1007/s00285-009-0262-y

The Wnt signalling pathway is involved in stem cell maintenance, differentiation and tissue development. Its disregulation has also been implicated in many cancers. β-catenin is a protein that regulates both transcription of many genes and cell-cell... Read More about A multiple timescale analysis of a mathematical model of the Wnt/β-catenin signalling pathway.

A computational study of discrete mechanical tissue models (2009)
Journal Article
Pathmanathan, P., Cooper, J., Fletcher, A., Mirams, G., Murray, P., Osborne, J., …Chapman, S. J. (2009). A computational study of discrete mechanical tissue models. Physical Biology, 6(3), Article 036001. https://doi.org/10.1088/1478-3975/6/3/036001

A computational study of discrete 'cell-centre' approaches to modelling the evolution of a collection of cells is undertaken. The study focuses on the mechanical aspects of the tissue, in order to separate the passive mechanical response of the model... Read More about A computational study of discrete mechanical tissue models.