All Outputs (2)

Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks (2014)
Journal Article
Chokkathukalam, A., Kim, D. H., Barrett, M. P., Breitling, R., & Creek, D. J. (2014). Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks. Bioanalysis, 6(4), 511-524. https://doi.org/10.4155/bio.13.348

The rapid emergence of metabolomics has enabled system-wide measurements of metabolites in various organisms. However, advances in the mechanistic understanding of metabolic networks remain limited, as most metabolomics studies cannot routinely provi... Read More about Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks.

A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells (2014)
Journal Article
Kim, D.-H., Allwood, J. W., Moore, R. E., Marsden-Edwards, E., Dunn, W. B., Xu, Y., …Goodacre, R. (2014). A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells. Molecular BioSystems, 10(3), 398-411. https://doi.org/10.1039/c3mb70423h

Recently, it has been reported that anti-viral drugs, such as indinavir and lopinavir (originally targeted for HIV), also inhibit E6-mediated proteasomal degradation of mutant p53 in E6-transfected C33A cells. In order to understand more about the mo... Read More about A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells.