Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial

Bath, Philip M; Scutt, Polly; Anderson, Craig S; Appleton, Jason P; Berge, Evind; Cala, Lesley; Dixon, Mark; England, Timothy M; Godolphin, Peter J; Havard, Diane; Haywood, Lee; Hepburn, Trish; Krishnan, Kailash; Mair, Grant; Montgomery, Alan A; Muir, Keith; Phillips, Stephen J; Pocock, Stuart; Potter, John; Price, Chris; Randall, Marc; Robinson, Thompson G; Roffe, Christine; Rothwell, Peter M; Sandset, Else C; Sanossian, Nerses; Saver, Jeffrey L; Shone, Angela; Niroshan Siriwardena, A; Wardlaw, Joanna M; Woodhouse, Lisa J; Venables, Graham; Sprigg, Nikola; Amarenco, Pierre; Muir, Keith; Amoils, Shannon; Jarvis, Malcolm; Rothwell, Peter M; Sandercock, Peter; Asplund, Kjell; Baigent, Colin; Ankolekar, Sandeep; Howard, Harriet; Lysons, Christopher; Walker, Gemma; Gregory, Hayley; Kirby, James; Smithson, Jennifer; Keeling, Joanne; Frowd, Nadia; Gray, Robert; Dooley, Richard; Clarke, Wim; Robinson, Patricia; Kang Law, Zhe; Hodgson, Sheila; Millington, Adam; Sakka, Eleni; Buchanan, David; Palmer, Jeb; Shaw, D; Cobb, H; Johnson, R; Payne, T; Spaight, R; Spaight, A; Sajid, M A; Whileman, A; Hall, E; Cripps, H; Toms, J; Gascoyne, R; Wright, S; Cooper, M; Palfreman, A; Rajapakse, A; Wynter, I; Musarrat, K; Mistri, A; Patel, C; Stephens, C; Khan, S; Patras, S; Soliman, M; Elmarimi, A; Hewitt, C; Watson, E; Wahishi, I; Hindle, J; Perkin, L; Wills, M; Arif, S; Leach, S; Butler, S; O'Kane, D; Smith, C; O'Callaghan, J; Sunman, W; Buck, A; Jackson, B; Richardson, C; Wilkes, G; Clarke, J; Ryan, L; Matias, O; Mangion, D; Hardwick, A; Constantin, C; Thomas, I; Netherton, K; Markova, S; Hedstrom, A; Rushton, B; Hyde, C; Scott, J; Blair, M; Maddula, M; Donnelly, R; Keane, S; Johnson, S; McKenzie, H; Banerjee, A; Hutchinson, D; Goodhand, H; Hill, J; Mellows, K; Cheeseman, M; McTaggart, V; Foster, T; Prothero, L; Saksena, P; O'Kelly, A; Wyllie, H; Hacon, C; Nutt, H; North, J; Goffin, K; Potter, J; Wiltshire, A; Ravenhill, G; Metcalf, K; Ford, L; Langley, M; Davison, W; Subramonian, S; Magezi, F; Obi, I; Temple, N; Butterworth-Cowin, N; Oqwusu-Agyei, P; Azim, A F M; Nicolson, A; Imam, J; White, J; Wood, L; Fothergill, R; Thompson, N; Lazarus, J; Werts, H; Sztriha, L; Ho, C; McKenzie, E; Owoyele, E; Lim, J; Aeron-Thomas, J; Dockey, M; Sylvester, N; Rao, P; Bloom, B M; Erumere, E; Norman, G; Skene, I; Cuenoud, L; Howaniec, L; Boulton, O; Daboo, P; Michael, R; Al-Saadi, S; Harrison, T; Syed, H; Argandona, L; Amiani, S; Perry, R; Ashton, A; Banaras, A; Hogan, C; Watchurst, C; Elliott, E; Francia, N; Oji, N; Erande, R; Obarey, S; Feerick, S; Tshuma, S; England, E; Pocock, H; Poole, K; Manchanda, S; Burn, I; Dayal, S; McNee, K; Robinson, M; Hancock, R; South, A; Holmes, C; Steele, A; Guthrie, L B; Oborn, M; Mohd Nor, A; Hyams, B; Eglinton, C; Waugh, D; Cann, E; Wilmhurst, N; Piesley, S; Shave, S; Dutta, D; Obeid, M; Ward, D; Turfrey, J; Glass, J; Bowstead, K; Hill, L; Brown, P; Beames, S; O'Connell, S; Hughes, V; Whiting, R; Gagg, J; Hussain, M; Harvey, M; Karunatilake, D; Pusuluri, B; Witcher, A; Pawley, C; Allen, J; Foot, J; Rowe, J; Lane, C; Ragab, S; Wadams, B; Dube, J; Jupp, B; Ljubez, A; Bagnall, C; Hann, G; Tucker, L; Kelton, M; Orr, S; Harrington, F; James, A; Lydon, A; Courtauld, G; Bond, K; Lucas, L; Nisbett, T; Kubie, J; Bowring, A; Jennings, G; Thorpe, K; Mason, N; Keenan, S; Gbadomishi, L; Howcroft, D; Newton, H; Choulerton, J; Avis, J; Shaw, L; Paterson, P; Kaye, P; Hierons, S; Lucas, S; Clatworthy, P; Faulkner, B; Rannigan, L; Worner, R; Bhaskaran, B; Saulat, A; Bearne, H; Garfield-Smith, J; Horan, K; Fitzell, P; Szabo, S; Haley, M; Simmons, D; Cotterill, D; Saunders, G; Dymond, H; Beech, S; Rashed, K; Tanate, A; Buckley, C; Wood, D; Matthews, L; Board, S; Pitt-Kirby, T; Rees, N; Convery, C; Jones, P; Bryant, C; Tench, H; Dixon, M; Loosley, R; Coetzee, S; Jones, S; Sims, T; Krishnan, M; Davies, C; Quinn, L; Connor, L; Wani, M; Storton, S; Treadwell, S; Anjum, T; Somashekar, C; Chandler, A; Triscott, C; Bevan, L; Sander, M; Buckle, S; Sayed, W; Andrews, K; Hughes, L; Hughes, R; Ward, M; Pretty, A; Rosser, A; Davidson, B; Price, G; Gunson, I; Lumley-Holmes, J; Miller, J; Larden, M; Jhamat, M; Horwood, P; Boldy, R; Jenkins, C; Price, F; Harrison, M; Martin, T; Ahmad, N; Willberry, A; Stevens, A; Fotherby, K; Barry, A; Remegoso, A; Alipio, F; Maquire, H; Hiden, J; Finney, K; Varquez, R; Ispoglou, S; Hayes, A; Gull, D; Evans, R; Epstein, E; Hurdowar, S; Crossley, J; Miles, J; Hird, K; Pilbery, R; Patterson, C; Ramadan, H; Stewart, K; Quinn, O; Bellfield, R; Macquire, S; Gaba, W; Nair, A; Wilson, A; Hawksworth, C; Alam, I; Greig, J; Robinson, M; Gomes, P; Rana, P; Ahmed, Z; Anderston, P; Neal, A; Walstow, D; Fong, R; Brotheridge, S; Bwalya, A; Gillespie, A; Midgley, C; Hare, C; Lyon, H; Stephenson, L; Broome, M; Worton, R; Jackson, S; Rayessa, R; Abdul-Hamid, A; Naylor, C; Clarkson, E; Hassan, A; Waugh, D; Veraque, E; Finch, L; Makawa, L; Carpenter, M; Datta, P; Needle, A; Jackson, L; Brooke, H J; Ball, J; Lowry, T; Punnoose, S; Walker, R; Murray, V; Ali, A; Kamara, C; Doyle, C; Richards, E; Howe, J; Dakin, K; Harkness, K; Lindert, R; Wanklyn, P; Willcoxson, P; Clark-Brown, P; Mir, R

doi:10.1016/S0140-6736(19)30194-1

All Outputs (5)

Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial (2023)
Journal Article
Desborough, M. J. R., Al-Shahi Salman, R., Stanworth, S. J., Havard, D., Woodhouse, L. J., Craig, J., …for DASH trial investigators, F. D. T. I. (2023). Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial. Lancet Neurology, 22(7), 557-567. https://doi.org/10.1016/S1474-4422%2823%2900157-6

Background: The risk of death from spontaneous intracerebral haemorrhage is increased for people taking antiplatelet drugs. We aimed to assess the feasibility of randomising patients on antiplatelet drug therapy with spontaneous intracerebral haemorr... Read More about Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial.

Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter)-a randomised placebo-controlled feasibility trial (2022)
Journal Article
Bath, P. M., Skinner, C. J. C., Bath, C. S., Woodhouse, L. J., Areti, A., Korovesi, K., …Gordon, A. L. (2022). Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter)-a randomised placebo-controlled feasibility trial. European Geriatric Medicine, 13, 1343-1355. https://doi.org/10.1007/s41999-022-00714-5

Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in ca... Read More about Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter)-a randomised placebo-controlled feasibility trial.

Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial (2022)
Journal Article
Tunnage, B., Woodhouse, L. J., Dixon, M., Anderson, C. S., Ankolekar, S., Appleton, J. P., …Bath, P. M. (2022). Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. BMC Emergency Medicine, 22(1), Article 2. https://doi.org/10.1186/s12873-021-00560-x

Background: Prehospital stroke trials will inevitably recruit patients with non-stroke conditions, so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in patients with mimics in the second Rapid Intervention with Glyc... Read More about Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial.

Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double blind randomised controlled feasibility trial (2020)
Journal Article
Desborough, M. J., Al-Shahi Salman, R., Stanworth, S. J., Havard, D., Brennan, P. M., Dineen, R. A., …DASH trial investigators. (2020). Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double blind randomised controlled feasibility trial. BMJ Open, 10(11), Article e037555. https://doi.org/10.1136/bmjopen-2020-037555

Introduction Intracerebral haemorrhage (ICH) can be devastating and is a common cause of death and disability worldwide. Pre-ICH antiplatelet drug use is associated with a 27% relative increase in 1 month case fatality compared with patients not usin... Read More about Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double blind randomised controlled feasibility trial.

Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial (2019)
Journal Article
Bath, P. M., Scutt, P., Anderson, C. S., Appleton, J. P., Berge, E., Cala, L., …Mir, R. (2019). Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial. Lancet, 393(10175), 1009-1020. https://doi.org/10.1016/S0140-6736%2819%2930194-1

© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: High blood pressure is common in acute stroke and is a predictor of poor outcome; however, large trials of lowering blood pressure... Read More about Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial.