A time-resolved Förster resonance energy transfer assay to investigate drug and inhibitor binding to ABCG2
(2024)
Journal Article
Mitchell-White, J. I., Briggs, D. A., Mistry, S. J., Mbiwan, H. A., Kellam, B., Holliday, N. D., …Kerr, I. D. (2024). A time-resolved Förster resonance energy transfer assay to investigate drug and inhibitor binding to ABCG2. Archives of Biochemistry and Biophysics, 753, Article 109915. https://doi.org/10.1016/j.abb.2024.109915
The human ATP-binding cassette (ABC) transporter, ABCG2, is responsible for multidrug resistance in some tumours. Detailed knowledge of its activity is crucial for understanding drug transport and resistance in cancer, and has implications for wider... Read More about A time-resolved Förster resonance energy transfer assay to investigate drug and inhibitor binding to ABCG2.