Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts

McWilliams, Daniel F.; Dawson, Olivia; Young, Adam; Kiely, Patrick; Ferguson, Eamonn; Walsh, David A.

doi:10.1016/j.jpain.2019.01.001

All Outputs (6)

Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae (2019)
Journal Article
McWilliams, D. F., Rahman, S., James, R., Ferguson, E., Kiely, P., Young, A., & Walsh, D. (2019). Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae. BMC Rheumatology, 3, 1-9. https://doi.org/10.1186/s41927-019-0100-9

Background RA flares are common and disabling. They are described in terms of worsening inflammation but pain and inflammation are often discordant. To inform treatment decisions, we investigated whether inflammatory and pain flares are discrete ent... Read More about Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae.

Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis (2019)
Journal Article
Georgopoulos, V., Akin-Akinyosoye, K., Zhang, W., McWilliams, D. F., Hendrick, P., & Walsh, D. A. (2019). Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis. PAIN, 160(9), 1920-1932. https://doi.org/10.1097/j.pain.0000000000001590

Hypersensitivity due to central pain mechanisms can influence recovery and lead to worse clinical outcomes, but the ability of quantitative sensory testing (QST), an index of sensitisation, to predict outcomes in chronic musculoskeletal disorders rem... Read More about Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis.

Trajectories of pain predict disabilities affecting daily living in arthritis (2019)
Journal Article
James, R. J., Walsh, D. A., & Ferguson, E. (2019). Trajectories of pain predict disabilities affecting daily living in arthritis. British Journal of Health Psychology, 24(3), 465-496. https://doi.org/10.1111/bjhp.12364

Purpose: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis heterogeneously, with subgroups of... Read More about Trajectories of pain predict disabilities affecting daily living in arthritis.

Contribution of sensory nerves within osteochondral channels to pain in human and rat knee osteoarthritis (2019)
Journal Article
Aso, K., Shahtaheri, S., Wilson, D., Hill, R., McWilliams, D., Walsh, D., & Chapman, V. (2019). Contribution of sensory nerves within osteochondral channels to pain in human and rat knee osteoarthritis. Osteoarthritis and Cartilage, 27(Supplelement 1), S72. https://doi.org/10.1016/j.joca.2019.02.102

Associations of symptomatic knee OA with histopathologic features in subchondral bone (2019)
Journal Article
McWilliams, D. F., shahtaheri, S., Walsh, D. A., Aso, K., Wilson, D., & Hill, R. (2019). Associations of symptomatic knee OA with histopathologic features in subchondral bone. Arthritis and Rheumatology, 71(6), 916-924. https://doi.org/10.1002/art.40820

© 2019, American College of Rheumatology Objective: Subchondral bone and the osteochondral junction are thought to contribute to osteoarthritis (OA) knee pain. We undertook this study to identify osteochondral pathologies specifically associated with... Read More about Associations of symptomatic knee OA with histopathologic features in subchondral bone.

Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts (2019)
Journal Article
McWilliams, D. F., Dawson, O., Young, A., Kiely, P., Ferguson, E., & Walsh, D. A. (2019). Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts. Journal of Pain, 20(6), 716-727. https://doi.org/10.1016/j.jpain.2019.01.001

Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesised that discrete RA subgroups might display favourable or unfa... Read More about Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts.