Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) shows efficacy against Osteosarcoma
(2020)
Journal Article
Reddy, G. B., Kerr, D. L., Spasojevic, I., Tovmasyan, A., Hsu, D. S., Brigman, B. E., …Eward, W. C. (2020). Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) shows efficacy against Osteosarcoma. Molecular Cancer Therapeutics, 19(7), 1448-1461. https://doi.org/10.1158/1535-7163.mct-19-0689
Therapeutic advances for osteosarcoma (OS) have stagnated over the past several decades, leading to an unmet clinical need for patients. The purpose of this study was to develop a novel therapy for OS by reformulating and validating niclosamide, an e... Read More about Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) shows efficacy against Osteosarcoma.